PMID- 22350620
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131211
LR  - 20211021
IS  - 1868-4483 (Print)
IS  - 1868-601X (Electronic)
IS  - 1868-4483 (Linking)
VI  - 2
IP  - 4
DP  - 2011 Dec 1
TI  - A neurovascular perspective for long-term changes after brain trauma.
PG  - 533-45
LID - 10.1007/s12975-011-0126-9 [doi]
AB  - Traumatic brain injury (TBI) affects all age groups in a population and is an 
      injury generating scientific interest not only as an acute event, but also as a 
      complex brain disease with several underlying neurobehavioral and 
      neuropathological characteristics. We review early and long-term alterations 
      after juvenile and adult TBI with a focus on changes in the neurovascular unit 
      (NVU), including neuronal interactions with glia and blood vessels at the 
      blood-brain barrier (BBB). Post-traumatic changes in cerebral blood-flow, BBB 
      structures and function, as well as mechanistic pathways associated with brain 
      aging and neurodegeneration are presented from clinical and experimental reports. 
      Based on the literature, increased attention on BBB changes should be integrated 
      in studies characterizing TBI outcome and may provide a meaningful therapeutic 
      target to resolve detrimental post-traumatic dysfunction.
FAU - Pop, V
AU  - Pop V
AD  - Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, 
      CA 92354 USA.
FAU - Badaut, J
AU  - Badaut J
LA  - eng
GR  - R01 HD061946/HD/NICHD NIH HHS/United States
GR  - R01 HD061946-01/HD/NICHD NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Transl Stroke Res
JT  - Translational stroke research
JID - 101517297
PMC - PMC3281750
MID - NIHMS338657
EDAT- 2012/02/22 06:00
MHDA- 2012/02/22 06:01
PMCR- 2012/12/01
CRDT- 2012/02/22 06:00
PHST- 2012/02/22 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2012/02/22 06:01 [medline]
PHST- 2012/12/01 00:00 [pmc-release]
AID - 10.1007/s12975-011-0126-9 [doi]
PST - ppublish
SO  - Transl Stroke Res. 2011 Dec 1;2(4):533-45. doi: 10.1007/s12975-011-0126-9.