PMID- 22351575
OWN - NLM
STAT- MEDLINE
DCOM- 20120531
LR  - 20211021
IS  - 1332-8166 (Electronic)
IS  - 0353-9504 (Print)
IS  - 0353-9504 (Linking)
VI  - 53
IP  - 1
DP  - 2012 Feb 15
TI  - The influence of tumor necrosis factor microsatellite polymorphisms on patient 
      survival following hematopoietic stem cell transplantation.
PG  - 24-9
AB  - AIM: To investigate the influence of tumor necrosis factor (TNF) microsatellite 
      polymorphisms on patient survival following hematopoietic stem cell 
      transplantation. METHODS: We analyzed TNFa, TNFb, and TNFd microsatellites among 
      100 patients who underwent allogeneic hematopoietic stem cell transplantation 
      from a human leukocyte antigen (HLA)-identical sibling donor at the Internal 
      Clinic of the University Hospital Center Zagreb in the period 2001-2009. The 
      analysis was performed using polymerase chain reaction amplification and 
      electrophoresis on a polyacrylamide gel in an automated sequencer. RESULTS: There 
      was no significant difference in patient survival with respect to the allele 
      length at a given microsatellite. However, a significantly lower survival rate 
      was noticed among patients who were positive for TNFa8 allele (P<0.001) and a 
      significantly higher survival rate among those who were positive for TNFa10 
      allele (P=0.0220). CONCLUSION: These results for the first time suggest an 
      influence of TNFa microsatellite on patient survival following HSCT and indicate 
      a need for further studies of this microsatellite.
FAU - Stingl, Katarina
AU  - Stingl K
AD  - Clinical Department for Transfusion Medicine and Transplantation Biology, 
      University Hospital Center Zagreb, Kispaticeva 12, Zagreb, Croatia. 
      kstingl@kbc-zagreb.hr
FAU - Zunec, Renata
AU  - Zunec R
FAU - Serventi-Seiwerth, Ranka
AU  - Serventi-Seiwerth R
FAU - Labar, Boris
AU  - Labar B
FAU - Grubic, Zorana
AU  - Grubic Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Croatia
TA  - Croat Med J
JT  - Croatian medical journal
JID - 9424324
RN  - 0 (Tumor Necrosis Factors)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Hematopoietic Stem Cell Transplantation/*mortality
MH  - Humans
MH  - Infant
MH  - *Microsatellite Repeats
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Single Nucleotide
MH  - Tumor Necrosis Factors/*genetics
MH  - Young Adult
PMC - PMC3284178
EDAT- 2012/02/22 06:00
MHDA- 2012/06/01 06:00
PMCR- 2012/02/01
CRDT- 2012/02/22 06:00
PHST- 2012/02/22 06:00 [entrez]
PHST- 2012/02/22 06:00 [pubmed]
PHST- 2012/06/01 06:00 [medline]
PHST- 2012/02/01 00:00 [pmc-release]
AID - CroatMedJ_53_0024 [pii]
AID - 10.3325/cmj.2012.53.24 [doi]
PST - ppublish
SO  - Croat Med J. 2012 Feb 15;53(1):24-9. doi: 10.3325/cmj.2012.53.24.