PMID- 22352282
OWN - NLM
STAT- MEDLINE
DCOM- 20120315
LR  - 20120222
IS  - 0017-7768 (Print)
IS  - 0017-7768 (Linking)
VI  - 150
IP  - 12
DP  - 2011 Dec
TI  - [Description of differential optical spectropolarimetric imaging system (DOSI) 
      for non-invasive detection of skin tumors].
PG  - 902-5, 936, 935
AB  - BACKGROUND: Most physicians diagnose skin malignancy using theoretical criteria 
      and clinical experience. Apart from dermatoscopy, noninvasive means for skin 
      tumors' diagnosis are highly expensive and are not in daily use. We developed a 
      simple, handy and relatively inexpensive tool for non-invasive diagnosis of skin 
      tumors. The Differential Optical Spectropolarimetric Imaging system (DOSI) is 
      based on collecting information from the surface and depth of skin tumors, using 
      the advantage of liquid crystal devices (LCDs]. OBJECTIVE: DOSI feasibility study 
      in order to diagnose skin tumors non-invasively. METHOD: Skin tumor optical data 
      was collected in order to create image indicators for specific skin tumors. 
      Spectral images of skin tumors are captured before the lesion that was scheduled 
      for removal was surgically excised. Repeating features of images of each tumor 
      type (which was histologically diagnosed) that characterize the specific tumor 
      and show distinction from the features of other tumors are recorded. RESULTS: The 
      feasibility of DOSI has been demonstrated for research, but it is not yet mature 
      for clinical use. Specific images, indicating specific skin tumors could not yet 
      be reliably concluded. One relatively obvious characteristic for malignancy seems 
      to be crescent-like and finger-like growth patterns. In the non-malignant 
      lesions: crescent and finger-like structures are of less pronounced orders of 
      magnitude. Crescents are more open and radius of curvature are of larger orders 
      of magnitude than in malignant specimen. DISCUSSION: The advantage of using LCD 
      is the ability to manipulate light electronically, without any movable 
      components. LCDs are the building blocks of optical filters and polarization 
      controllers. Using optical filters and polarization controllers, we are able to 
      electronically manipulate the polarization and wavelength of our light source 
      without any movable components. The light source emits different wavelengths 
      (colors) that penetrate the tissue at different depths. The camera (CCD) captures 
      the diffused reflected light from a skin lesion as a sequence of images for each 
      polarization stage. By applying our novel method for each polarization stage we 
      are able to overcome the noise of the diffused reflection and emphasize the 
      scattering areas. Emphasizing the scattering areas provided images that may 
      indicate malignancy. CONCLUSIONS: The feasibility of DOSI has been demonstrated. 
      In order to obtain reliable diagnostic image indicators for specific skin tumors, 
      more clinical tests are necessary.
FAU - Arnon, Ofer
AU  - Arnon O
AD  - Department of PLastic and Reconstructive Surgery and Burn Unit, Soroka, 
      University Medical Center, Ben Gurion University of the Negev. 
      oferarnon@gmail.com
FAU - Aharon, Ofir
AU  - Aharon O
FAU - Silberstain, Eldad
AU  - Silberstain E
FAU - Bogdanov-Berezovsky, Alexander
AU  - Bogdanov-Berezovsky A
FAU - Krieger, Yuval
AU  - Krieger Y
FAU - Rosenberg, Lior
AU  - Rosenberg L
FAU - Abdulhalim, Ibrahim
AU  - Abdulhalim I
LA  - heb
PT  - English Abstract
PT  - Journal Article
PL  - Israel
TA  - Harefuah
JT  - Harefuah
JID - 0034351
SB  - IM
MH  - Equipment Design
MH  - Feasibility Studies
MH  - Humans
MH  - Liquid Crystals/*chemistry
MH  - Optical Devices
MH  - Skin Neoplasms/*diagnosis/pathology
MH  - Spectrum Analysis/*methods
EDAT- 2012/02/23 06:00
MHDA- 2012/03/16 06:00
CRDT- 2012/02/23 06:00
PHST- 2012/02/23 06:00 [entrez]
PHST- 2012/02/23 06:00 [pubmed]
PHST- 2012/03/16 06:00 [medline]
PST - ppublish
SO  - Harefuah. 2011 Dec;150(12):902-5, 936, 935.