PMID- 22352672
OWN - NLM
STAT- MEDLINE
DCOM- 20120524
LR  - 20190930
IS  - 1560-2281 (Electronic)
IS  - 1083-3668 (Linking)
VI  - 17
IP  - 1
DP  - 2012 Jan
TI  - Silica-on-silicon waveguide integrated polydimethylsiloxane lab-on-a-chip for 
      quantum dot fluorescence bio-detection.
PG  - 017006
LID - 10.1117/1.JBO.17.1.017006 [doi]
AB  - Integration of microfluidics and optical components is an essential requirement 
      for the realization of optical detection in lab-on-a-chip (LOC). In this work, a 
      novel hybrid integration of silica-on-silicon (SOS) waveguide and 
      polydymethylsiloxane (PDMS) microfluidics for realizing optical detection based 
      biochip is demonstrated. SOS is a commonly used platform for integrated photonic 
      circuits due to its lower absorption coefficient of silica and the availability 
      of advanced microfabrication technologies for fabricating complicated optical 
      components. However, the fabrication of complex microfluidics circuits on SOS is 
      an expensive process. On the other hand, any complex 3D and high-aspect-ratio 
      microstructures for the microfluidic applications can be easily patterned on PDMS 
      using soft lithography. By exploring the advantages of these two materials, the 
      proposed hybrid integration method greatly simplifies the fabrication of optical 
      LOC. Two simple technologies--namely, diamond machining and soft 
      lithography--were employed for the integration of an optical microfluidic system. 
      Use of PDMS for the fabrication of any complex 3D microfluidics structures, 
      together with the integration of low loss silica-on-silicon photonic waveguides 
      with a straight microfluidic channel, opens up new possibilities to produce 
      low-cost biochips. The performance of SOS-PDMS-integrated hybrid biochip is 
      demonstrated with the detection of laser induced fluorescence of quantum dots. As 
      quantum dots have immense application potential for biodetection, they are used 
      for the demonstration of biodetection.
FAU - Ozhikandathil, Jayan
AU  - Ozhikandathil J
AD  - Concordia University, Optical-Bio Microsystems Laboratory, Department of 
      Mechanical and Industrial Engineering, Montreal, QC, Canada. 
      j_ozhik@encs.concordia.ca
FAU - Packirisamy, Muthukumaran
AU  - Packirisamy M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biomed Opt
JT  - Journal of biomedical optics
JID - 9605853
RN  - 0 (Dimethylpolysiloxanes)
RN  - 63148-62-9 (baysilon)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - Z4152N8IUI (Silicon)
SB  - IM
MH  - Dimethylpolysiloxanes/*chemistry
MH  - Equipment Design
MH  - Microfluidic Analytical Techniques/*instrumentation/methods
MH  - *Quantum Dots
MH  - Silicon/*chemistry
MH  - Silicon Dioxide/*chemistry
MH  - Spectrometry, Fluorescence/*instrumentation/methods
EDAT- 2012/02/23 06:00
MHDA- 2012/05/25 06:00
CRDT- 2012/02/23 06:00
PHST- 2012/02/23 06:00 [entrez]
PHST- 2012/02/23 06:00 [pubmed]
PHST- 2012/05/25 06:00 [medline]
AID - 10.1117/1.JBO.17.1.017006 [doi]
PST - ppublish
SO  - J Biomed Opt. 2012 Jan;17(1):017006. doi: 10.1117/1.JBO.17.1.017006.