PMID- 22352750
OWN - NLM
STAT- MEDLINE
DCOM- 20120719
LR  - 20190728
IS  - 1873-4286 (Electronic)
IS  - 1381-6128 (Linking)
VI  - 18
IP  - 13
DP  - 2012
TI  - Clinical applications and biosafety of human adult mesenchymal stem cells.
PG  - 1821-45
AB  - Mesenchymal Stem Cells (MSCs) are a population of adherent cells that can 
      differentiate into mesenchymal lineage populations (cartilage, bone and fat 
      tissue). In addition, they seem to be able to differentiate also into a broader 
      type of lineages other than the original mesodermal germ layer. Bone marrow MSCs 
      are a standard in the field of adult stem cell biology and clinical applications; 
      however adipose-derived MSCs are becoming an attractive alternative due to their 
      minimally invasive accessibility and availability in the body. MSCs modulate 
      several effector immune functions by interacting both with innate and adoptive 
      immune responses. Several local signals from the tissue microenvironment, 
      together with cytokine and soluble factors released by MSCs influence 
      anti-inflammatory and tissue repair properties of infused MSCs. Therefore, 
      cellular therapies utilizing ex vivo expanded MSCs may be an interesting approach 
      for inflammatory and autoimmune diseases. Biosafety is still one of the most 
      important aspects; therefore the production of clinical-grade MSCs requires the 
      careful identification and control of all the phases of cell manipulation and 
      release. Many clinical applications of adult MSCs are in progress and are using 
      bone marrow or adipose tissue-derived MSCs for the treatment of Graft Versus Host 
      Disease (GVHD), inflammatory joint diseases and osteocartilagineous defects, 
      digestive tract, cardiovascular and neurological diseases.
FAU - Mariani, E
AU  - Mariani E
AD  - Laboratorio di Immunoreumatologia e Rigenerazione Tissutale and Laboratorio 
      RAMSES, Rizzoli Orthopedic Institute, Bologna, Dipartimento di Medicina Clinica, 
      University of Bologna, Italy. erminia.mariani@unibo.it
FAU - Facchini, A
AU  - Facchini A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - Curr Pharm Des
JT  - Current pharmaceutical design
JID - 9602487
SB  - IM
MH  - Adult
MH  - Graft vs Host Disease/immunology/*therapy
MH  - Humans
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/*cytology
MH  - *Safety
EDAT- 2012/02/23 06:00
MHDA- 2012/07/20 06:00
CRDT- 2012/02/23 06:00
PHST- 2011/11/11 00:00 [received]
PHST- 2011/12/08 00:00 [accepted]
PHST- 2012/02/23 06:00 [entrez]
PHST- 2012/02/23 06:00 [pubmed]
PHST- 2012/07/20 06:00 [medline]
AID - CPD-EPUB-20120119-003 [pii]
AID - 10.2174/138161212799859666 [doi]
PST - ppublish
SO  - Curr Pharm Des. 2012;18(13):1821-45. doi: 10.2174/138161212799859666.