PMID- 22354326
OWN - NLM
STAT- MEDLINE
DCOM- 20120723
LR  - 20211021
IS  - 1573-4838 (Electronic)
IS  - 0957-4530 (Linking)
VI  - 23
IP  - 4
DP  - 2012 Apr
TI  - Self-assembled nanomicelles using PLGA-PEG amphiphilic block copolymer for 
      insulin delivery: a physicochemical investigation and determination of CMC 
      values.
PG  - 943-53
LID - 10.1007/s10856-012-4562-1 [doi]
AB  - Self-assembled nanomicelles can be used as synthetic biomaterials and colloidal 
      carriers for poorly water-soluble drug delivery systems. Some of these micellar 
      systems have been introduced in clinical trials and showed hopeful results 
      relating to their therapeutic index in patients. Biodegradable nanomicelle was 
      prepared from self-assembling amphiphilic block copolymer composed of 
      poly(DL-lactic-co-glycolic acid) (PLGA) as a core and polyethylene glycol (PEG) 
      as a corona. The PLGA-PEG block copolymer was first synthesized and characterized 
      by FTIR, (1)H NMR, GPC and inherent viscosity measurements. The nanomicelle 
      formed by PLGA-PEG block copolymer in the aqueous solution was characterized by 
      dynamic light scattering, zeta potential, scanning electron microscopy (SEM) and 
      fluorescence excitation and emission spectra of pyrene probe. The critical 
      micelle concentration of obtained nanomicelle was about 0.006 mg/mL, with the 
      size of about 160 nm and the zeta potential of -29 mV. Insulin-loaded PLGA-PEG 
      nanomicelles were prepared by modified dialysis method and the physicochemical 
      parameters of the micelles such as drug content, entrapment efficiency and in 
      vitro drug release were characterized. The results showed that insulin was 
      entrapped into PLGA-PEG nanomicelles with drug loading of 3.9 wt% and entrapment 
      efficiency of 55 wt%. The nanomicelles containing insulin exhibited a controlled 
      release profile. These observations suggested that the PLGA-PEG block copolymers 
      nanomicelles have been prepared by a new synthetic route are potent nanocarrier 
      for poorly water-soluble drugs as insulin.
FAU - Ashjari, Mohsen
AU  - Ashjari M
AD  - Polymer Science Department, Iran Polymer & Petrochemical Institute, Tehran, Iran. 
      m.ashjari@ippi.ac.ir
FAU - Khoee, Sepideh
AU  - Khoee S
FAU - Mahdavian, Ali Reza
AU  - Mahdavian AR
FAU - Rahmatolahzadeh, Reza
AU  - Rahmatolahzadeh R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120222
PL  - United States
TA  - J Mater Sci Mater Med
JT  - Journal of materials science. Materials in medicine
JID - 9013087
RN  - 0 (Drug Carriers)
RN  - 0 (Insulin)
RN  - 0 (Micelles)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
SB  - IM
MH  - Drug Carriers
MH  - Insulin/*administration & dosage
MH  - Lactic Acid/*chemistry
MH  - Magnetic Resonance Spectroscopy
MH  - Micelles
MH  - Microscopy, Electron, Scanning
MH  - Polyethylene Glycols/*chemistry
MH  - Polyglycolic Acid/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Spectroscopy, Fourier Transform Infrared
EDAT- 2012/02/23 06:00
MHDA- 2012/07/24 06:00
CRDT- 2012/02/23 06:00
PHST- 2011/06/29 00:00 [received]
PHST- 2012/01/25 00:00 [accepted]
PHST- 2012/02/23 06:00 [entrez]
PHST- 2012/02/23 06:00 [pubmed]
PHST- 2012/07/24 06:00 [medline]
AID - 10.1007/s10856-012-4562-1 [doi]
PST - ppublish
SO  - J Mater Sci Mater Med. 2012 Apr;23(4):943-53. doi: 10.1007/s10856-012-4562-1. 
      Epub 2012 Feb 22.