PMID- 22355790
OWN - NLM
STAT- MEDLINE
DCOM- 20130412
LR  - 20211021
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 2
DP  - 2012
TI  - A therapeutic method for the direct reprogramming of human liver cancer cells 
      with only chemicals.
PG  - 280
LID - 10.1038/srep00280 [doi]
LID - 280
AB  - Various methods for the direct reprogramming of human somatic cells have been 
      developed. However, a therapeutic method to reprogram and eliminate human solid 
      tumor cells has not been developed. Here we show a novel therapeutic method to 
      reprogram and eliminate human solid tumor cells with chemicals. This therapeutic 
      method may be applicable to various human solid tumor cells that express 
      aldo-keto reductase family 1 member B10 (AKR1B10) and retinoid X receptors 
      (RXRs).
FAU - Moriguchi, Hisashi
AU  - Moriguchi H
FAU - Zhang, Yue
AU  - Zhang Y
FAU - Mihara, Makoto
AU  - Mihara M
FAU - Sato, Chifumi
AU  - Sato C
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20120221
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Retinoids)
RN  - EC 1.1.1.- (AKR1B10 protein, human)
RN  - EC 1.1.1.- (Aldo-Keto Reductases)
RN  - EC 1.1.1.21 (Aldehyde Reductase)
SB  - IM
RIN - Sci Rep. 2012;2:839. PMID: 23326632
MH  - Aldehyde Reductase/metabolism
MH  - Aldo-Keto Reductases
MH  - Carcinoma, Hepatocellular/enzymology/metabolism/*pathology
MH  - Humans
MH  - Liver Neoplasms/enzymology/metabolism/*pathology
MH  - Liver Transplantation
MH  - Oxygen Consumption
MH  - Retinoid X Receptors/metabolism
MH  - Retinoids/*pharmacology
PMC - PMC3282982
EDAT- 2012/02/23 06:00
MHDA- 2012/02/23 06:01
PMCR- 2012/02/21
CRDT- 2012/02/23 06:00
PHST- 2011/09/14 00:00 [received]
PHST- 2011/12/23 00:00 [accepted]
PHST- 2012/02/23 06:00 [entrez]
PHST- 2012/02/23 06:00 [pubmed]
PHST- 2012/02/23 06:01 [medline]
PHST- 2012/02/21 00:00 [pmc-release]
AID - srep00280 [pii]
AID - 10.1038/srep00280 [doi]
PST - ppublish
SO  - Sci Rep. 2012;2:280. doi: 10.1038/srep00280. Epub 2012 Feb 21.