PMID- 22356900
OWN - NLM
STAT- MEDLINE
DCOM- 20140630
LR  - 20121008
IS  - 1618-0372 (Electronic)
IS  - 0065-1281 (Linking)
VI  - 114
IP  - 8
DP  - 2012 Dec
TI  - Expression of Th1 and Th2 cytokine-associated transcription factors, T-bet and 
      GATA-3, in the eutopic endometrium of women with endometriosis.
PG  - 779-84
LID - S0065-1281(12)00006-2 [pii]
LID - 10.1016/j.acthis.2012.01.005 [doi]
AB  - The objective of the present study was to evaluate the expression of T-box 
      expressed in T cells (T-bet) and GATA binding protein 3 (GATA-3) in the eutopic 
      endometrium from women with endometriosis. Endometrial tissues were collected 
      from 20 women with laparoscopically confirmed endometriosis and 20 women without 
      endometriosis. T-bet and GATA-3 expression was measured by quantitative real-time 
      PCR (qPCR), immunohistochemistry and Western blot analysis. Eutopic endometrial 
      tissues from patients with endometriosis expressed lower levels of T-bet mRNA and 
      high levels of GATA-3 mRNA, leading to a significant lower T-bet/GATA-3 mRNA 
      ratio (P<0.05). Western blot analysis showed that the T-bet/GATA-3 protein ratio 
      in endometriosis group was also statistically lower than that in the control 
      group (P<0.05). These results suggested that T-bet and GATA-3 may act as cytokine 
      regulatory genes, and the Th2-specific transcription factor, GATA-3, probably 
      plays an essential role in the immune response and the development of 
      endometriosis.
CI  - Copyright (c) 2012 Elsevier GmbH. All rights reserved.
FAU - Chen, Peng
AU  - Chen P
AD  - Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China 
      Medical University, Shenyang, People's Republic of China.
FAU - Zhang, Zhifang
AU  - Zhang Z
FAU - Chen, Qi
AU  - Chen Q
FAU - Ren, Fang
AU  - Ren F
FAU - Li, Tong
AU  - Li T
FAU - Zhang, Chiyuan
AU  - Zhang C
FAU - Wang, Danbo
AU  - Wang D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120220
PL  - Germany
TA  - Acta Histochem
JT  - Acta histochemica
JID - 0370320
RN  - 0 (Cytokines)
RN  - 0 (GATA3 Transcription Factor)
RN  - 0 (RNA, Messenger)
RN  - 0 (T-Box Domain Proteins)
RN  - 0 (T-box transcription factor TBX21)
SB  - IM
MH  - Adult
MH  - Blotting, Western
MH  - Cytokines/*genetics
MH  - Endometriosis/*genetics/pathology
MH  - Endometrium/*metabolism/pathology
MH  - Female
MH  - GATA3 Transcription Factor/*analysis/*genetics
MH  - Humans
MH  - Immunohistochemistry
MH  - RNA, Messenger/analysis/genetics
MH  - Real-Time Polymerase Chain Reaction
MH  - T-Box Domain Proteins/*analysis/*genetics
MH  - Th1 Cells/metabolism
MH  - Th2 Cells/metabolism
EDAT- 2012/02/24 06:00
MHDA- 2014/07/01 06:00
CRDT- 2012/02/24 06:00
PHST- 2011/12/08 00:00 [received]
PHST- 2012/01/16 00:00 [revised]
PHST- 2012/01/17 00:00 [accepted]
PHST- 2012/02/24 06:00 [entrez]
PHST- 2012/02/24 06:00 [pubmed]
PHST- 2014/07/01 06:00 [medline]
AID - S0065-1281(12)00006-2 [pii]
AID - 10.1016/j.acthis.2012.01.005 [doi]
PST - ppublish
SO  - Acta Histochem. 2012 Dec;114(8):779-84. doi: 10.1016/j.acthis.2012.01.005. Epub 
      2012 Feb 20.