PMID- 22358133
OWN - NLM
STAT- MEDLINE
DCOM- 20120612
LR  - 20170707
IS  - 0386-300X (Print)
IS  - 0386-300X (Linking)
VI  - 66
IP  - 1
DP  - 2012
TI  - Heat shock protein magic in antigen trafficking within dendritic cells: 
      implications in antigen cross-presentation in immunity.
PG  - 1-6
AB  - Dendritic cells (DCs) take up soluble- or cell-associated antigens and digest 
      them, delivering fragments to the MHC class I pathway to display antigenic 
      peptides to CD8(+) T cells, a process known as cross-presentation. The pathway 
      requires that, in order to be degraded by proteosomes, the extracellular antigens 
      must have access to the cytosol across the endosomal membranes. Although the 
      cross-presentation phenomena was first identified in the 1970s, the molecular 
      mechanism responsible for the translocation is still not fully understood. In 
      this context, we have recently found that cytosolic heat shock protein (HSP)90 
      translocates internalized antigen to the cytosol in DCs. Our results revealed the 
      important role that cytosolic HSP90 plays in cross-presentation by pulling out 
      endosomal antigen to the cytosol.
FAU - Udono, Heiichiro
AU  - Udono H
AD  - Department of Immunology, Okayama University Graduate School of Medicine, 
      Dentistry and Pharmaceutical Sciences, Japan. udono@cc.okayama-u.ac.jp
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Acta Med Okayama
JT  - Acta medica Okayama
JID - 0417611
RN  - 0 (HSP90 Heat-Shock Proteins)
SB  - IM
MH  - Animals
MH  - *Antigen Presentation
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - *Cross-Priming
MH  - Cytosol/immunology
MH  - Dendritic Cells/*immunology
MH  - Endosomes/immunology
MH  - HSP90 Heat-Shock Proteins/*physiology
MH  - Humans
MH  - Lymphocyte Activation
MH  - Protein Transport
EDAT- 2012/02/24 06:00
MHDA- 2012/06/13 06:00
CRDT- 2012/02/24 06:00
PHST- 2012/02/24 06:00 [entrez]
PHST- 2012/02/24 06:00 [pubmed]
PHST- 2012/06/13 06:00 [medline]
AID - 10.18926/AMO/48075 [doi]
PST - ppublish
SO  - Acta Med Okayama. 2012;66(1):1-6. doi: 10.18926/AMO/48075.