PMID- 22359877
OWN - NLM
STAT- MEDLINE
DCOM- 20120320
LR  - 20120224
IS  - 1330-0164 (Print)
IS  - 1330-0164 (Linking)
VI  - 65
IP  - 2
DP  - 2011
TI  - [Increasing incidence of angioedema without urticaria--clinical features].
PG  - 119-27
AB  - The causes of angioedema (AE), a self-limited, localized swelling of subcutaneous 
      tissue or mucosa unaccompanied by urticaria, are diverse. The commonly applied 
      label of "allergic" is frequently wrong and standard anti-allergic therapy can be 
      ineffective. Types of AE could be categorized according to mediators which 
      mediate vascular leakage: bradykinin AE (hereditary, acquired, 
      angiotensin-converting enzyme inhibitor (ACEi)-related), histamine AE (allergic 
      etiology), and various mediators mediated AE (pseudoallergic reaction to 
      non-steroidal anti-inflammatory drugs). Idiopathic AE is a poorly understood 
      syndrome. The growing relevance of AE without urticaria has been highlighted; 
      angioedema is the most common cause of hospital admission among all acute 
      allergic diseases. The diagnosis of AE is based on the presence of family history 
      (hereditary), absence of family history with the onset during or after the fourth 
      decade of life (acquired C1lnh deficiency), and treatment with ACEi (ACEi-related 
      angioedema). About 0.1%-0.7% of patients taking ACEi develop angioedema as a 
      well-documented but still frequently unrecognized side effect of drugs. 
      Laboratory diagnosis is enabled by measuring serum levels of C1lnh antigen or 
      C1lnh function. Type 1 (hereditary angioedema (HAE) was diagnosed when both 
      antigenic and functional levels of C1lnh were below 50% of normal, and type 2 
      when functional levels of C1lnh were low, along with antigenic levels normal or 
      higher. ACEi-related AE is diagnosed when AE recurs during therapy and disappears 
      upon withdrawal. Symptoms may appear several years after therapy introduction. 
      Severe acute attacks should be treated with C1lnh concentrate and icatibant, a 
      selective and specific antagonist of bradykinin B2 receptors. Prophylaxis with 
      attenuated androgens (danazol, stanazolol, oxandrolone) is effective in 
      preventing symptom development.
FAU - Markovic, Asja Stipic
AU  - Markovic AS
AD  - Department of Clinical Immunology, Pulmonology and Rheumatology, University 
      Department of Medicine, Sveti Duh University Hospital, Zagreb, Croatia.
FAU - Janzekovic, Martina
AU  - Janzekovic M
LA  - hrv
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Trend povecane incidencije angioedema bez urtikarije--klinicke osobitosti.
PL  - Croatia
TA  - Acta Med Croatica
JT  - Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti
JID - 9208249
SB  - IM
MH  - Angioedema/classification/complications/*diagnosis/epidemiology
MH  - Angioedemas, Hereditary/diagnosis
MH  - Diagnosis, Differential
MH  - Drug Hypersensitivity/complications/diagnosis
MH  - Humans
MH  - Incidence
MH  - Urticaria/complications
EDAT- 2012/03/01 06:00
MHDA- 2012/03/21 06:00
CRDT- 2012/02/25 06:00
PHST- 2012/02/25 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2012/03/21 06:00 [medline]
PST - ppublish
SO  - Acta Med Croatica. 2011;65(2):119-27.