PMID- 22360541
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20221207
IS  - 1442-200X (Electronic)
IS  - 1328-8067 (Linking)
VI  - 54
IP  - 4
DP  - 2012 Aug
TI  - Insulin resistance at diagnosis in Japanese children with type 2 diabetes 
      mellitus.
PG  - 516-9
LID - 10.1111/j.1442-200X.2012.03596.x [doi]
AB  - BACKGROUND: Insulin resistance at diagnosis was investigated in Japanese children 
      with type 2 diabetes mellitus (T2DM). METHODS: A total of 160 children with T2DM 
      were divided into groups on the basis of percent overweight at time of diagnosis: 
      group A (n = 28), <20%; group B (n = 55), 20-39%; group C (n = 37), 40-59%; group 
      D (n = 40), >/= 60%. Indicators of insulin resistance at diagnosis were compared 
      among the four patient groups, and also between the children with T2DM and the 
      201 age-matched normal Japanese children. RESULTS: There were no significant 
      differences in plasma glucose (PG) levels among the four patient groups. The mean 
      concentration of fasting plasma immunoreactive insulin (IRI) was significantly 
      higher in group D than in groups A and B (39.2 microU/mL vs 16.2 microU/mL and 24.1 
      microU/mL, P < 0.05, respectively). The mean homeostasis model assessment (HOMA-R) 
      was significantly higher in group D than in all the other three groups (17.6 vs 
      7.8, 10.8 and 12.7, P < 0.05, respectively). The indicators HOMA-R and fasting 
      IRI were significantly higher in each diabetes group, even in non-obese group A, 
      than in normal children (P < 0.01, respectively). CONCLUSIONS: Japanese children 
      with T2DM had insulin resistance at diagnosis regardless of percent overweight, 
      and the degree of insulin resistance gradually increased with rise in percent 
      overweight.
CI  - (c) 2012 The Authors. Pediatrics International (c) 2012 Japan Pediatric Society.
FAU - Urakami, Tatsuhiko
AU  - Urakami T
AD  - Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan. 
      urakami.tatsuhiko@nihon-u.ac.jp
FAU - Habu, Masako
AU  - Habu M
FAU - Kuwabara, Remi
AU  - Kuwabara R
FAU - Komiya, Kei
AU  - Komiya K
FAU - Nagano, Nobuhiko
AU  - Nagano N
FAU - Suzuki, Junichi
AU  - Suzuki J
FAU - Mugishima, Hideo
AU  - Mugishima H
LA  - eng
PT  - Journal Article
DEP - 20120425
PL  - Australia
TA  - Pediatr Int
JT  - Pediatrics international : official journal of the Japan Pediatric Society
JID - 100886002
SB  - IM
MH  - Adolescent
MH  - Asian People
MH  - Child
MH  - Diabetes Mellitus, Type 2/diagnosis/*metabolism
MH  - Female
MH  - Humans
MH  - *Insulin Resistance
MH  - Male
EDAT- 2012/03/01 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/02/25 06:00
PHST- 2012/02/25 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - 10.1111/j.1442-200X.2012.03596.x [doi]
PST - ppublish
SO  - Pediatr Int. 2012 Aug;54(4):516-9. doi: 10.1111/j.1442-200X.2012.03596.x. Epub 
      2012 Apr 25.