PMID- 22361238
OWN - NLM
STAT- MEDLINE
DCOM- 20121031
LR  - 20181201
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 44
DP  - 2012 Sep
TI  - Circulating levels of persistent organic pollutants (POPs) among elderly men and 
      women from Sweden: results from the Prospective Investigation of the Vasculature 
      in Uppsala Seniors (PIVUS).
PG  - 59-67
LID - 10.1016/j.envint.2012.01.011 [doi]
AB  - Persistent Organic Pollutants (POPs) are a huge group of chemicals that have been 
      linked to various adverse health effects in humans. Large epidemiological studies 
      investigating gender differences in levels of POPs in the elderly are limited and 
      the results from these are not always consistent. The present study was 
      undertaken to examine the background levels of a broad range of POPs in human 
      plasma samples among elderly men and women from Sweden and to assess the 
      influence of gender. Levels of 23 POPs were determined in plasma samples 
      collected during 2001-2004 from 1016 (50.2% women) 70year-old participants from 
      the population-based Prospective Study of the Vasculature in Uppsala Seniors 
      (PIVUS). Measurements were performed using high resolution gas chromatography 
      with high resolution mass spectrometry (HRGC-HRMS) and the POPs studied were 16 
      polychlorinated biphenyls (PCBs), five organochlorine (OC) pesticides, one 
      dioxin, and one brominated flame retardant. The concentrations of the selected 
      POPs were found similar, or comparable, to other studies of non-occupationally 
      exposed populations from Sweden and Europe. Differences in levels of POPs between 
      men and women were assessed by using Wilcoxon rank-sum (Mann-Whitney) test. 
      Significant (p<0.0001) gender differences in levels of specific POPs were 
      observed and a number of POP concentrations were found to differ between men and 
      women. More specifically, levels of HCB, OCDD, and PCB congeners #74, #105, and 
      #118 were found to be higher in women, while the rest of the majority of POPs 
      were higher in men.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Salihovic, Samira
AU  - Salihovic S
AD  - MTM Research Centre, School of Science and Technology, Orebro University, Orebro, 
      Sweden. samira.salihovic@oru.se
FAU - Lampa, Erik
AU  - Lampa E
FAU - Lindstrom, Gunilla
AU  - Lindstrom G
FAU - Lind, Lars
AU  - Lind L
FAU - Lind, P Monica
AU  - Lind PM
FAU - van Bavel, Bert
AU  - van Bavel B
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120222
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 4Z87H0LKUY (Hexachlorobenzene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Aged
MH  - Dioxins/blood
MH  - Environmental Exposure/analysis/*statistics & numerical data
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Hexachlorobenzene
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood
MH  - Male
MH  - Pesticides/blood
MH  - Polychlorinated Biphenyls/blood
MH  - Polychlorinated Dibenzodioxins/blood
MH  - Sex Factors
MH  - Sweden
EDAT- 2012/03/01 06:00
MHDA- 2012/11/01 06:00
CRDT- 2012/02/25 06:00
PHST- 2011/08/02 00:00 [received]
PHST- 2012/01/24 00:00 [revised]
PHST- 2012/01/24 00:00 [accepted]
PHST- 2012/02/25 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2012/11/01 06:00 [medline]
AID - S0160-4120(12)00021-9 [pii]
AID - 10.1016/j.envint.2012.01.011 [doi]
PST - ppublish
SO  - Environ Int. 2012 Sep;44:59-67. doi: 10.1016/j.envint.2012.01.011. Epub 2012 Feb 
      22.