PMID- 22363233
OWN - NLM
STAT- MEDLINE
DCOM- 20120629
LR  - 20220922
IS  - 1660-3397 (Electronic)
IS  - 1660-3397 (Linking)
VI  - 10
IP  - 1
DP  - 2012 Jan
TI  - Antibacterial bisabolane-type sesquiterpenoids from the sponge-derived fungus 
      Aspergillus sp.
PG  - 234-241
LID - 10.3390/md10010234 [doi]
AB  - Four new bisabolane-type sesquiterpenoids, aspergiterpenoid A (1), (-)-sydonol 
      (2), (-)-sydonic acid (3), and 
      (-)-5-(hydroxymethyl)-2-(2',6',6'-trimethyltetrahydro-2H- pyran-2-yl)phenol (4) 
      together with one known fungal metabolite (5) were isolated from the fermentation 
      broth of a marine-derived fungus Aspergillus sp., which was isolated from the 
      sponge Xestospongia testudinaria collected from the South China Sea. Four of them 
      (1-4) are optically active compounds. Their structures and absolute 
      configurations were elucidated by using NMR spectroscopic techniques and mass 
      spectrometric analysis, and by comparing their optical rotations with those 
      related known analogues. Compounds 1-5 showed selective antibacterial activity 
      against eight bacterial strains with the MIC (minimum inhibiting concentrations) 
      values between 1.25 and 20.0 microM. The cytotoxic, antifouling, and 
      acetylcholinesterase inhibitory activities of these compounds were also examined.
FAU - Li, Dan
AU  - Li D
AD  - Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and 
      Pharmacy, Ocean University of China, Qingdao 266003, China.
FAU - Xu, Ying
AU  - Xu Y
AD  - KAUST Global Academic Partnership Program, Division of Life Science, The Hong 
      Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
FAU - Shao, Chang-Lun
AU  - Shao CL
AD  - Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and 
      Pharmacy, Ocean University of China, Qingdao 266003, China.
FAU - Yang, Rui-Yun
AU  - Yang RY
AD  - Key Laboratory for the Chemistry and Molecular Engineering of Medicinal 
      Resources, Ministry of Education, School of Chemistry & Chemical Engineering, 
      Guangxi Normal University, Guilin 541004, China.
FAU - Zheng, Cai-Juan
AU  - Zheng CJ
AD  - Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and 
      Pharmacy, Ocean University of China, Qingdao 266003, China.
FAU - Chen, Yi-Yan
AU  - Chen YY
AD  - Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and 
      Pharmacy, Ocean University of China, Qingdao 266003, China.
FAU - Fu, Xiu-Mei
AU  - Fu XM
AD  - Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and 
      Pharmacy, Ocean University of China, Qingdao 266003, China.
FAU - Qian, Pei-Yuan
AU  - Qian PY
AD  - KAUST Global Academic Partnership Program, Division of Life Science, The Hong 
      Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
FAU - She, Zhi-Gang
AU  - She ZG
AD  - School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 
      510275, China.
FAU - Voogd, Nicole J de
AU  - Voogd NJ
AD  - Netherlands Centre for Biodiversity Naturalis, P.O. Box 9517, Leiden 2300 RA, The 
      Netherlands.
FAU - Wang, Chang-Yun
AU  - Wang CY
AD  - Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and 
      Pharmacy, Ocean University of China, Qingdao 266003, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120119
PL  - Switzerland
TA  - Mar Drugs
JT  - Marine drugs
JID - 101213729
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Sesquiterpenes)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*isolation & purification/pharmacology
MH  - Aspergillus/chemistry/*metabolism
MH  - Magnetic Resonance Spectroscopy
MH  - Microbial Sensitivity Tests
MH  - Porifera/*microbiology
MH  - Sesquiterpenes/chemistry/*isolation & purification/pharmacology
PMC - PMC3280534
OTO - NOTNLM
OT  - Aspergillus sp.
OT  - antibacterial
OT  - bisabolane-type sesquiterpenoid
OT  - sponge-derived fungus
EDAT- 2012/03/01 06:00
MHDA- 2012/06/30 06:00
PMCR- 2012/01/01
CRDT- 2012/02/25 06:00
PHST- 2011/11/20 00:00 [received]
PHST- 2011/12/19 00:00 [revised]
PHST- 2011/12/22 00:00 [accepted]
PHST- 2012/02/25 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2012/06/30 06:00 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - md10010234 [pii]
AID - marinedrugs-10-00234 [pii]
AID - 10.3390/md10010234 [doi]
PST - ppublish
SO  - Mar Drugs. 2012 Jan;10(1):234-241. doi: 10.3390/md10010234. Epub 2012 Jan 19.