PMID- 22363844
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 2090-4606 (Electronic)
IS  - 2090-4592 (Print)
IS  - 2090-4592 (Linking)
VI  - 2011
DP  - 2011
TI  - The pathogenesis of Candida infections in a human skin model: scanning electron 
      microscope observations.
PG  - 150642
LID - 10.5402/2011/150642 [doi]
LID - 150642
AB  - Cutaneous candidiasis is an opportunistic infection that arises, in most cases, 
      from endogenous, saprophytic candidal blastospores that selectively colonize 
      oral, gastrointestinal, vaginal, and cutaneous epithelium. Candida albicans has 
      been regarded as the most common causative agent in human fungal infections. 
      However, other Candida species have become a significant cause of infection. 
      Scanning electron microscope (SEM) observations were used to analyze the 
      capability of C. albicans, C. tropicalis, and C. parapsilosis to adhere to human 
      skin model, used in this study, which was found to mimic the human skin in vivo. 
      The skin sections were inoculated with low and high concentration of the yeasts 
      and followed for 1 and 5 days; then they were viewed by SEM. The electron 
      microscopy observations revealed that all three yeasts tested adhered to the skin 
      but C. albicans covered the entire skin model to a higher extent than C. 
      tropicalis or C. parapsilosis. Mucin-like material coated the blastoconidia 
      mainly in C. albicans. All Candida species have shown characteristics resembling 
      biofilm formation. The use of human skin sections for ex vivo evaluation of 
      adherence of various yeasts may partially explain the predominance of C. albicans 
      in cutaneous pathogenicity.
FAU - Raz-Pasteur, A
AU  - Raz-Pasteur A
AD  - Departement of Microbiology, The Ruth and Bruce Rappaport Faculty of Medicine, 
      Technion-Institute of Technology, P.O. Box 9649, 31096 Haifa, Israel.
FAU - Ullmann, Y
AU  - Ullmann Y
FAU - Berdicevsky, I
AU  - Berdicevsky I
LA  - eng
PT  - Journal Article
DEP - 20110905
PL  - Egypt
TA  - ISRN Dermatol
JT  - ISRN dermatology
JID - 101566611
PMC - PMC3262537
EDAT- 2012/03/01 06:00
MHDA- 2012/03/01 06:01
PMCR- 2011/09/05
CRDT- 2012/02/25 06:00
PHST- 2011/05/16 00:00 [received]
PHST- 2011/06/13 00:00 [accepted]
PHST- 2012/02/25 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2012/03/01 06:01 [medline]
PHST- 2011/09/05 00:00 [pmc-release]
AID - 10.5402/2011/150642 [doi]
PST - ppublish
SO  - ISRN Dermatol. 2011;2011:150642. doi: 10.5402/2011/150642. Epub 2011 Sep 5.