PMID- 22364391
OWN - NLM
STAT- MEDLINE
DCOM- 20120514
LR  - 20221207
IS  - 1471-2350 (Electronic)
IS  - 1471-2350 (Linking)
VI  - 13
DP  - 2012 Feb 24
TI  - The combined effect of the T2DM susceptibility genes is an important risk factor 
      for T2DM in non-obese Japanese: a population based case-control study.
PG  - 11
LID - 10.1186/1471-2350-13-11 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is a complex endocrine and metabolic 
      disorder. Recently, several genome-wide association studies (GWAS) have 
      identified many novel susceptibility loci for T2DM, and indicated that there are 
      common genetic causes contributing to the susceptibility to T2DM in multiple 
      populations worldwide. In addition, clinical and epidemiological studies have 
      indicated that obesity is a major risk factor for T2DM. However, the prevalence 
      of obesity varies among the various ethnic groups. We aimed to determine the 
      combined effects of these susceptibility loci and obesity/overweight for 
      development of T2DM in the Japanese. METHODS: Single nucleotide polymorphisms 
      (SNPs) in or near 17 susceptibility loci for T2DM, identified through GWAS in 
      Caucasian and Asian populations, were genotyped in 333 cases with T2DM and 417 
      control subjects. RESULTS: We confirmed that the cumulative number of risk 
      alleles based on 17 susceptibility loci for T2DM was an important risk factor in 
      the development of T2DM in Japanese population (P<0.0001), although the effect of 
      each risk allele was relatively small. In addition, the significant association 
      between an increased number of risk alleles and an increased risk of T2DM was 
      observed in the non-obese group (P<0.0001 for trend), but not in the 
      obese/overweight group (P=0.88 for trend). CONCLUSIONS: Our findings indicate 
      that there is an etiological heterogeneity of T2DM between obese/overweight and 
      non-obese subjects.
FAU - Yamakawa-Kobayashi, Kimiko
AU  - Yamakawa-Kobayashi K
AD  - Laboratory of Human Genetics, School of Food and Nutritional Sciences, Graduate 
      School of Nutritional and Environmental Sciences, Global COE Program, University 
      of Shizuoka, Shizuoka 422-8526, Japan. kobayasi@u-shizuoka-ken.ac.jp
FAU - Natsume, Maki
AU  - Natsume M
FAU - Aoki, Shingo
AU  - Aoki S
FAU - Nakano, Sachi
AU  - Nakano S
FAU - Inamori, Tomoko
AU  - Inamori T
FAU - Kasezawa, Nobuhiko
AU  - Kasezawa N
FAU - Goda, Toshinao
AU  - Goda T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120224
PL  - England
TA  - BMC Med Genet
JT  - BMC medical genetics
JID - 100968552
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Asian People/*genetics
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/etiology/*genetics
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - Genotype
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Obesity/genetics
MH  - Odds Ratio
MH  - Overweight
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
PMC - PMC3313886
EDAT- 2012/03/01 06:00
MHDA- 2012/05/15 06:00
PMCR- 2012/02/24
CRDT- 2012/02/28 06:00
PHST- 2011/09/02 00:00 [received]
PHST- 2012/02/24 00:00 [accepted]
PHST- 2012/02/28 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2012/05/15 06:00 [medline]
PHST- 2012/02/24 00:00 [pmc-release]
AID - 1471-2350-13-11 [pii]
AID - 10.1186/1471-2350-13-11 [doi]
PST - epublish
SO  - BMC Med Genet. 2012 Feb 24;13:11. doi: 10.1186/1471-2350-13-11.