PMID- 22365902
OWN - NLM
STAT- MEDLINE
DCOM- 20120613
LR  - 20120430
IS  - 1471-5007 (Electronic)
IS  - 1471-4922 (Linking)
VI  - 28
IP  - 5
DP  - 2012 May
TI  - Are plasmacytoid dendritic cells the misguided sentinels of malarial immunity?
PG  - 182-6
LID - 10.1016/j.pt.2012.01.007 [doi]
AB  - Dendritic cells (DCs), the sentinels of immunity, reside in almost every organ of 
      the body. These cells are responsible for initiating immune responses against 
      infectious agents. DCs are divided into different subsets based on their 
      biological functions, with plasmacytoid DCs (pDCs) and conventional DCs (cDCs) 
      being two major populations. The ability of DCs to protect against malaria 
      infection was recently questioned when pDCs were reported to be a reservoir for 
      rodent Plasmodium spp. in the spleen. This opinion article explores how the 
      occupation of pDCs by the parasite may corrupt immunity against malaria.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Wykes, Michelle N
AU  - Wykes MN
AD  - The Queensland Institute of Medical Research, The Bancroft Centre, 300 Herston 
      Road, Brisbane, Queensland 4006, Australia. Michelle.Wykes@qimr.edu.au
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120225
PL  - England
TA  - Trends Parasitol
JT  - Trends in parasitology
JID - 100966034
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology/*parasitology
MH  - Humans
MH  - Malaria/*immunology/*parasitology
MH  - Mice
MH  - Plasmodium/physiology
EDAT- 2012/03/01 06:00
MHDA- 2012/06/14 06:00
CRDT- 2012/02/28 06:00
PHST- 2012/01/05 00:00 [received]
PHST- 2012/01/28 00:00 [revised]
PHST- 2012/01/30 00:00 [accepted]
PHST- 2012/02/28 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2012/06/14 06:00 [medline]
AID - S1471-4922(12)00019-0 [pii]
AID - 10.1016/j.pt.2012.01.007 [doi]
PST - ppublish
SO  - Trends Parasitol. 2012 May;28(5):182-6. doi: 10.1016/j.pt.2012.01.007. Epub 2012 
      Feb 25.