PMID- 22365968
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20211021
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 73
IP  - 5
DP  - 2012 May
TI  - Comprehensive identification of high-frequency and co-occurring Mafa-B, 
      Mafa-DQB1, and Mafa-DRB alleles in cynomolgus macaques of Vietnamese origin.
PG  - 547-53
LID - 10.1016/j.humimm.2012.02.003 [doi]
AB  - High-frequency alleles and/or co-occurring human leukocyte antigen (HLA) alleles 
      across loci appear to be more important than individual alleles, because they 
      might be markers of disease risk that have clinical value as biomarkers for 
      targeted screening or the development of new therapies. To better elucidate the 
      major histocompatibility complex background and to facilitate the experimental 
      use of cynomolgus macaques, Mafa-B, Mafa-DQB1, and Mafa-DRB alleles were 
      characterized and their combinations were investigated from 30 macaques of 
      Vietnamese origin by cloning and sequencing. A total of 48 Mafa-B, 22 Mafa-DQB1, 
      and 42 Mafa-DRB alleles, were detected in this study, respectively. In addition, 
      two Mafa-DQB1 and eight Mafa-DRB alleles represented novel sequences that had not 
      been documented in earlier studies. Our results also showed that the macaque from 
      Vietnam might be valuable because >30% of the test animals possessed 
      Mafa-DRB*w304 (30%) and -DQB1*0616 (30%). We report that the combination of major 
      histocompatibility complex (MHC) class I and II alleles, including the 
      combination of DRB3*0403-DRB*w304, DRB1*1013-DRB*w304, and 
      Mafa-B*007:01:01-DRB*w304, which was in 17%, 13%, and 13% of the animals, 
      respectively. Interesting, more than two Mafa-DQB1 alleles detected in one animal 
      in this study suggest that Mafa-DQB1, like Mafa-DRB, might be a duplication in 
      the chromosome, which have ever been documented in cynomolgus monkeys but has not 
      yet been observed in rhesus macaques or other primates. Our results for the high 
      frequency of commonly co-occurring MHC alleles across loci in a cohort of the 
      Vietnamese cynomolgus macaque emphasized the value of this species as a model for 
      biomedical research.
CI  - Copyright (c) 2012 American Society for Histocompatibility and Immunogenetics. All 
      rights reserved.
FAU - Ling, Fei
AU  - Ling F
AD  - School of Bioscience and Bioengineering, South China University of Technology, 
      Guangzhou 510006, P.R. China.
FAU - Zhuo, Min
AU  - Zhuo M
FAU - Ni, Chao
AU  - Ni C
FAU - Zhang, Gui-Qing
AU  - Zhang GQ
FAU - Wang, Tao
AU  - Wang T
FAU - Li, Wai
AU  - Li W
FAU - Wei, Li-Qiong
AU  - Wei LQ
FAU - Du, Hong-Li
AU  - Du HL
FAU - Wang, Ju-Fang
AU  - Wang JF
FAU - Wang, Xiao-Ning
AU  - Wang XN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120209
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - *Alleles
MH  - Animals
MH  - Cloning, Molecular
MH  - Gene Duplication
MH  - Gene Frequency
MH  - Genetic Loci
MH  - Histocompatibility Antigens Class I/*genetics/immunology
MH  - Histocompatibility Antigens Class II/*genetics/immunology
MH  - Humans
MH  - Macaca fascicularis/*genetics/immunology
MH  - Models, Biological
MH  - Recombinant Proteins/genetics/immunology
MH  - Sequence Analysis, DNA
MH  - Vietnam
PMC - PMC7115533
EDAT- 2012/03/01 06:00
MHDA- 2013/01/19 06:00
PMCR- 2012/02/09
CRDT- 2012/02/28 06:00
PHST- 2011/06/29 00:00 [received]
PHST- 2012/01/24 00:00 [revised]
PHST- 2012/02/01 00:00 [accepted]
PHST- 2012/02/28 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
PHST- 2012/02/09 00:00 [pmc-release]
AID - S0198-8859(12)00031-6 [pii]
AID - 10.1016/j.humimm.2012.02.003 [doi]
PST - ppublish
SO  - Hum Immunol. 2012 May;73(5):547-53. doi: 10.1016/j.humimm.2012.02.003. Epub 2012 
      Feb 9.