PMID- 22365996
OWN - NLM
STAT- MEDLINE
DCOM- 20130712
LR  - 20181201
IS  - 1673-4254 (Print)
IS  - 1673-4254 (Linking)
VI  - 32
IP  - 1
DP  - 2012 Jan
TI  - [Endothelial dysfunction induced by high glucose is associated with decreased 
      ATP-binding cassette transporter G1 expression].
PG  - 14-8
AB  - OBJECTIVE: To investigate the role of ATP-binding cassette transporter G1 (ABCG1) 
      in endothelial dysfunction induced by high glucose. METHODS: Human aortic 
      endothelial cells (HAECs) were incubated in the presence of 5.6 or 30 mmol/L 
      glucose for 24-72 h with or without a 2-h pretreatment with the LXR agonist 
      22(R)-hydroxycholesterol. Real-time PCR and Western blotting were used to measure 
      the mRNA and protein expressions of ABCG1; the intracellular cholesterol efflux 
      and endothelial nitric oxide synthase (eNOS) activity were measured by 
      scintillation counting. RESULTS: High glucose time-dependently suppressed ABCG1 
      expression and cholesterol efflux to HDL in HAECs. High glucose also decreased 
      eNOS activity. ABCG1 down-regulation induced by high glucose, along with 
      decreased cholesterol efflux and eNOS activity, was abolished by treatment of the 
      cells with the LXR agonist. CONCLUSION: Endothelial dysfunction induced by high 
      glucose is associated with decreased ABCG1 expression.
FAU - Xue, Jiahong
AU  - Xue J
AD  - Department of Cardiovascular Medicine, Xi'an Jiaotong University College of 
      Medicine, Xi'an, China. xjh1224@163.com
FAU - Niu, Xiaolin
AU  - Niu X
FAU - Wei, Jin
AU  - Wei J
FAU - Dong, Xin
AU  - Dong X
FAU - Zhu, Canzhan
AU  - Zhu C
FAU - Dang, Yinhu
AU  - Dang Y
FAU - Song, Anqi
AU  - Song A
FAU - Huang, Huimei
AU  - Huang H
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
RN  - 0 (ABCG1 protein, human)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily G, Member 1)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily G, Member 1
MH  - ATP-Binding Cassette Transporters/genetics/*metabolism
MH  - Aorta/*cytology
MH  - Cell Line
MH  - Down-Regulation/drug effects
MH  - Endothelial Cells/cytology/metabolism/*physiology
MH  - Glucose/*pharmacology
MH  - Humans
EDAT- 2012/03/01 06:00
MHDA- 2013/07/16 06:00
CRDT- 2012/02/28 06:00
PHST- 2012/02/28 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2013/07/16 06:00 [medline]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2012 Jan;32(1):14-8.