PMID- 22366091
OWN - NLM
STAT- MEDLINE
DCOM- 20120508
LR  - 20181201
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 419
IP  - 3
DP  - 2012 Mar 16
TI  - Silibinin inhibits the toxic aggregation of human islet amyloid polypeptide.
PG  - 495-9
LID - 10.1016/j.bbrc.2012.02.042 [doi]
AB  - In type 2 diabetes mellitus (T2DM), misfolded human islet amyloid polypeptide 
      (hIAPP) forms amyloid deposits in pancreatic islets. These amyloid deposits 
      contribute to the dysfunction of beta-cells and the loss of beta-cell mass in T2DM 
      patients. Inhibition of hIAPP fibrillization has been regarded as a potential 
      therapeutic approach for T2DM. Silibinin, a major active flavonoid extracted from 
      herb milk thistle (Silybum marianum), has been used for centuries to treat 
      diabetes in Asia and Europe with unclear mechanisms. In this study, we tested 
      whether silibinin has any effect on the amyloidogenicity of hIAPP. Our results 
      provide first evidence that silibinin inhibits hIAPP fibrillization via 
      suppressing the toxic oligomerization of hIAPP and enhances the viability of 
      pancreatic beta-cells, therefore silibinin may serve as a potential therapeutic 
      agent for T2DM.
CI  - Copyright A(c) 2012 Elsevier Inc. All rights reserved.
FAU - Cheng, Biao
AU  - Cheng B
AD  - Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, 
      Hubei, PR China.
FAU - Gong, Hao
AU  - Gong H
FAU - Li, Xiaochao
AU  - Li X
FAU - Sun, Yue
AU  - Sun Y
FAU - Zhang, Xin
AU  - Zhang X
FAU - Chen, Hong
AU  - Chen H
FAU - Liu, Xinran
AU  - Liu X
FAU - Zheng, Ling
AU  - Zheng L
FAU - Huang, Kun
AU  - Huang K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120214
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Antioxidants)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Islet Amyloid Polypeptide)
RN  - 0 (Silymarin)
RN  - 4RKY41TBTF (Silybin)
SB  - IM
MH  - Amino Acid Sequence
MH  - Antioxidants/*pharmacology
MH  - Humans
MH  - Hypoglycemic Agents/*pharmacology
MH  - Insulin-Secreting Cells/*drug effects/metabolism
MH  - Islet Amyloid Polypeptide/*antagonists & inhibitors/chemistry/metabolism
MH  - Molecular Sequence Data
MH  - Protein Conformation/drug effects
MH  - Silybin
MH  - Silymarin/*pharmacology
EDAT- 2012/03/01 06:00
MHDA- 2012/05/09 06:00
CRDT- 2012/02/28 06:00
PHST- 2012/01/30 00:00 [received]
PHST- 2012/02/07 00:00 [accepted]
PHST- 2012/02/28 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2012/05/09 06:00 [medline]
AID - S0006-291X(12)00262-8 [pii]
AID - 10.1016/j.bbrc.2012.02.042 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2012 Mar 16;419(3):495-9. doi: 
      10.1016/j.bbrc.2012.02.042. Epub 2012 Feb 14.