PMID- 22367481
OWN - NLM
STAT- MEDLINE
DCOM- 20120703
LR  - 20221207
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 5
IP  - 5
DP  - 2012 May
TI  - Association of human leukocyte antigen-DRB1 alleles with chronic hepatitis B 
      virus infection in the Han Chinese of Northeast China.
PG  - 1347-51
LID - 10.3892/mmr.2012.800 [doi]
AB  - Human leukocyte antigen (HLA) class II molecule is an integral component of the 
      immune response on which the majority of host genetic studies have concentrated. 
      Many different HLA-II alleles have been demonstrated to play roles in HBV 
      infection. PCR-SSOP methods were applied to determine the HLA-DRB1 genotypes of 
      769 unrelated healthy individuals from Han Chinese of Northeast China. The 
      frequencies of HLA-DRB1*09 in hepatitis B virus (HBV)-infected subjects were 
      higher compared to those in the control group. Frequencies of HLA-DRB1*04 and *13 
      in the HBV-infected group were significantly lower compared to those in the 
      healthy control group. Frequencies of HLA-DRB1*12 in the cirrhosis and liver 
      cancer groups were significantly higher than those in the chronic hepatitis B 
      (CHB) patients. The frequency of LA-DRB1*03 in the CHB patient group was 
      significantly higher compared to that in the asymptomatic hepatitis B carrier 
      patients. The above results suggest that the host HLA-II gene is an important 
      factor in the determination of the outcome of HBV infection.
FAU - Han, Yu
AU  - Han Y
AD  - Jilin Blood Center, Changchun, Jilin 130033, PR China.
FAU - Jiang, Zhen-Yu
AU  - Jiang ZY
FAU - Jiao, Li-Xin
AU  - Jiao LX
FAU - Yao, Cheng
AU  - Yao C
FAU - Lin, Qian-Fei
AU  - Lin QF
FAU - Ma, Ning
AU  - Ma N
FAU - Ju, Rui-Qing
AU  - Ju RQ
FAU - Yang, Fan
AU  - Yang F
FAU - Yu, Jiang-Hong
AU  - Yu JH
FAU - Chen, Lin
AU  - Chen L
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20120220
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*04 antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Alleles
MH  - Asian People/ethnology
MH  - China/epidemiology/ethnology
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - HLA-DRB1 Chains/*genetics/immunology
MH  - *Hepatitis B virus
MH  - Hepatitis B, Chronic/epidemiology/*genetics/immunology
MH  - Humans
MH  - Liver Cirrhosis/epidemiology/genetics/immunology/virology
MH  - Male
MH  - Middle Aged
EDAT- 2012/03/01 06:00
MHDA- 2012/07/04 06:00
CRDT- 2012/02/28 06:00
PHST- 2011/11/12 00:00 [received]
PHST- 2012/02/13 00:00 [accepted]
PHST- 2012/02/28 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2012/07/04 06:00 [medline]
AID - 10.3892/mmr.2012.800 [doi]
PST - ppublish
SO  - Mol Med Rep. 2012 May;5(5):1347-51. doi: 10.3892/mmr.2012.800. Epub 2012 Feb 20.