PMID- 22368185
OWN - NLM
STAT- MEDLINE
DCOM- 20130607
LR  - 20141120
IS  - 1522-9645 (Electronic)
IS  - 0195-668X (Linking)
VI  - 34
IP  - 2
DP  - 2013 Jan
TI  - Scar extent, left ventricular end-diastolic volume, and wall motion abnormalities 
      identify high-risk patients with previous myocardial infarction: a 
      multiparametric approach for prognostic stratification.
PG  - 104-11
LID - 10.1093/eurheartj/ehs037 [doi]
AB  - AIMS: We sought to investigate whether combining left ventricular (LV) volumes, 
      regional wall motion abnormalities, and scar tissue extent obtained by cardiac 
      magnetic resonance (CMR) improves risk stratification of patients with previous 
      myocardial infarction (MI). METHODS AND RESULTS: In 231 consecutive patients (age 
      64 +/- 11 years, males 89%) with previous MI, we quantified LV volumes and regional 
      wall motion abnormalities by cine CMR, and measured the extent of the infarction 
      scar by late gadolinium enhancement (LGE). During follow-up (median, 3.2 years) 
      cardiac events (cardiac death or appropriate intra-cardiac defibrillator shocks) 
      occurred in 19 patients. After adjustment for age, an extent of LGE >12.7%, an LV 
      end-diastolic volume >105 mL/m(2), and a wall motion score index >1.7 were 
      independent associated with adverse cardiac events at multivariate analysis (P < 
      0.05, P < 0.001, and P < 0.01, respectively). The patients with none of these 
      factors, and those with one or two factors, showed a lower risk of cardiac events 
      [hazard ratio (HR) = 0.112, P < 0.01 and HR = 0.261, P < 0.05] than those with 
      three factors. The cumulative event-rate estimated at 4 years was 29.6% in 
      patients with all three factors, 7.7% in those with one or two factors, and 3.5% 
      in patients with none of these factors. CONCLUSION: A multiparametric CMR 
      approach, which includes the measure of scar tissue extent, LV end-diastolic 
      volume and regional wall motion abnormalities, improves risk stratification of 
      patients with previous MI.
FAU - Di Bella, Gianluca
AU  - Di Bella G
AD  - CNR, Institute of Clinical Physiology, G. Monasterio Foundation, Via Moruzzi, 1, 
      56124, Pisa, Italy.
FAU - Siciliano, Valeria
AU  - Siciliano V
FAU - Aquaro, Giovanni Donato
AU  - Aquaro GD
FAU - Molinaro, Sabrina
AU  - Molinaro S
FAU - Lombardi, Massimo
AU  - Lombardi M
FAU - Carerj, Scipione
AU  - Carerj S
FAU - Landi, Patrizia
AU  - Landi P
FAU - Rovai, Daniele
AU  - Rovai D
FAU - Pingitore, Alessandro
AU  - Pingitore A
LA  - eng
PT  - Journal Article
DEP - 20120224
PL  - England
TA  - Eur Heart J
JT  - European heart journal
JID - 8006263
SB  - IM
MH  - Cicatrix/*pathology
MH  - Death, Sudden, Cardiac/etiology
MH  - Defibrillators, Implantable
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Magnetic Resonance Angiography
MH  - Male
MH  - Middle Aged
MH  - *Myocardial Infarction/pathology/physiopathology/prevention & control
MH  - Prognosis
MH  - Risk Assessment
MH  - Risk Factors
MH  - Secondary Prevention
MH  - Stroke Volume/*physiology
EDAT- 2012/03/01 06:00
MHDA- 2013/06/08 06:00
CRDT- 2012/02/28 06:00
PHST- 2012/02/28 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2013/06/08 06:00 [medline]
AID - ehs037 [pii]
AID - 10.1093/eurheartj/ehs037 [doi]
PST - ppublish
SO  - Eur Heart J. 2013 Jan;34(2):104-11. doi: 10.1093/eurheartj/ehs037. Epub 2012 Feb 
      24.