PMID- 22368195
OWN - NLM
STAT- MEDLINE
DCOM- 20130107
LR  - 20161125
IS  - 2047-2412 (Electronic)
IS  - 2047-2404 (Linking)
VI  - 13
IP  - 9
DP  - 2012 Sep
TI  - Impact of type 2 diabetes on serial changes in tissue characteristics of coronary 
      plaques: an integrated backscatter intravascular ultrasound analysis.
PG  - 717-23
LID - 10.1093/ehjci/jes033 [doi]
AB  - AIMS: Several studies have demonstrated that type 2 diabetes mellitus (T2DM) is 
      associated with accelerated atherosclerosis, which results in an increased risk 
      of coronary vascular events. However, serial changes in plaque characteristics 
      have not been reported in vivo. We evaluated the progression of coronary 
      atherosclerosis in patients with T2DM using an integrated backscatter 
      intravascular ultrasound (IB-IVUS) examination. METHODS AND RESULTS: Forty-two 
      T2DM and 48 non-diabetic patients who underwent percutaneous coronary 
      intervention were enrolled in the study. Non-culprit 20-mm length coronary 
      lesions with mild-to-moderate stenosis were measured using a 40-MHz (motorized 
      pullback of 0.5 mm/s) IVUS catheter. IVUS examinations were performed on one 
      target lesion in each patient. Six months later, a follow-up IVUS examination was 
      repeated in the same coronary segment imaged at the baseline examination. T2DM 
      patients demonstrated a greater total plaque volume (TPV; 139 +/- 53 vs. 114 +/- 45 
      mm(3), P = 0.02) and total lipid volume (TLV; 67 +/- 26 vs. 55 +/- 30 mm(3), P = 
      0.039) at the baseline examination. The progression of TPV (8.6 +/- 15.4 vs. -2.2 +/- 
      16.0%, P < 0.01) and TLV (10.8 +/- 28.8 vs. -2.5 +/- 20.0%, P < 0.05) from the 
      baseline was observed in T2DM patients, but not in non-diabetic patients. The 
      increase in TLV was blunted in T2DM patients who achieved HbA1c levels of <6.5%. 
      CONCLUSION: Accelerated plaque progression with an increase in the lipid-rich 
      component of non-culprit plaques was observed in T2DM, despite the use of 
      standard medical treatment. Better glycaemic control ameliorated the worsening of 
      plaque characteristics in T2DM.
FAU - Inaba, Shinji
AU  - Inaba S
AD  - Division of Cardiology, Department of Integrated Medicine and Informatics, Ehime 
      University Graduate School of Medicine, Toon, Ehime, Japan.
FAU - Okayama, Hideki
AU  - Okayama H
FAU - Funada, Jun-ichi
AU  - Funada J
FAU - Higashi, Haruhiko
AU  - Higashi H
FAU - Saito, Makoto
AU  - Saito M
FAU - Yoshii, Toyofumi
AU  - Yoshii T
FAU - Hiasa, Go
AU  - Hiasa G
FAU - Sumimoto, Takumi
AU  - Sumimoto T
FAU - Takata, Yasunori
AU  - Takata Y
FAU - Nishimura, Kazuhisa
AU  - Nishimura K
FAU - Inoue, Katsuji
AU  - Inoue K
FAU - Ogimoto, Akiyoshi
AU  - Ogimoto A
FAU - Higaki, Jitsuo
AU  - Higaki J
LA  - eng
PT  - Journal Article
DEP - 20120224
PL  - England
TA  - Eur Heart J Cardiovasc Imaging
JT  - European heart journal. Cardiovascular Imaging
JID - 101573788
SB  - IM
MH  - Aged
MH  - Chi-Square Distribution
MH  - Coronary Artery Disease/*diagnostic imaging/pathology/therapy
MH  - Diabetes Mellitus, Type 2/*diagnostic imaging
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Percutaneous Coronary Intervention
MH  - Plaque, Atherosclerotic/*diagnostic imaging/pathology/therapy
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - Statistics, Nonparametric
MH  - Ultrasonography, Interventional/*methods
EDAT- 2012/03/01 06:00
MHDA- 2013/01/08 06:00
CRDT- 2012/02/28 06:00
PHST- 2012/02/28 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2013/01/08 06:00 [medline]
AID - jes033 [pii]
AID - 10.1093/ehjci/jes033 [doi]
PST - ppublish
SO  - Eur Heart J Cardiovasc Imaging. 2012 Sep;13(9):717-23. doi: 10.1093/ehjci/jes033. 
      Epub 2012 Feb 24.