PMID- 22368417
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 0976-5018 (Electronic)
IS  - 0976-500X (Print)
IS  - 0976-500X (Linking)
VI  - 3
IP  - 1
DP  - 2012 Jan
TI  - A randomized comparative study of safety and efficacy of immediate release 
      glucosamine HCL and glucosamine HCL sustained release formulation in the 
      treatment of knee osteoarthritis: A proof of concept study.
PG  - 48-54
LID - 10.4103/0976-500X.92515 [doi]
AB  - OBJECTIVES: To compare the safety and efficacy of glucosamine HCl- sustained 
      release (GLU-SR) with that of Glucosamine HCl- immediate release (GLU-IR) in 
      patients with knee osteoarthritis (OA). MATERIALS AND METHODS: This study 
      involved 59 patients with knee OA, randomised to receive single oral dose of 
      1,500 mg, GLU-SR and GLU-IR for 60 days with 31 and 28 patients, respectively. 
      The primary efficacy (pain and function) was assessed using visual analogue scale 
      (VAS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) 
      scores. Intention-to-treat principle, repeated measure of ANOVA and mixed model 
      analysis were used. RESULTS: The patients baseline, demographic and clinical 
      characteristics were comparable between groups with female preponderance 
      (71.20%). There was a significant reduction in algofunctional indices as primary 
      outcome measure in both the groups across time (P < 0.001) and 29% lesser adverse 
      events (AEs) in GLU-SR group, with no difference in the use of rescue 
      medications. CONCLUSIONS: The study showed equal efficacy of the glucosamine 
      formulations on algofunctional indices in reducing pain in patients with knee OA 
      with less number of AEs in GLU-SR.
FAU - Kulkarni, Chanda
AU  - Kulkarni C
AD  - Division of Clinical Pharmacology, Department of Pharmacology,St. John's Medical 
      College, Bengaluru, Karnataka, India.
FAU - Leena, A
AU  - Leena A
FAU - Lohit, K
AU  - Lohit K
FAU - Mishra, Devesh
AU  - Mishra D
FAU - Saji, M J
AU  - Saji MJ
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Pharmacol Pharmacother
JT  - Journal of pharmacology & pharmacotherapeutics
JID - 101552113
PMC - PMC3284037
OTO - NOTNLM
OT  - Glucosamine
OT  - immediate release
OT  - osteoarthritis
OT  - sustained release
COIS- Conflict of Interest: None declared.
EDAT- 2012/03/01 06:00
MHDA- 2012/03/01 06:01
PMCR- 2012/01/01
CRDT- 2012/02/28 06:00
PHST- 2012/02/28 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2012/03/01 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - JPP-3-48 [pii]
AID - 10.4103/0976-500X.92515 [doi]
PST - ppublish
SO  - J Pharmacol Pharmacother. 2012 Jan;3(1):48-54. doi: 10.4103/0976-500X.92515.