PMID- 22368440
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1177-5483 (Electronic)
IS  - 1177-5467 (Print)
IS  - 1177-5467 (Linking)
VI  - 6
DP  - 2012
TI  - Bilateral choroidal neovascularization associated with optic nerve head drusen 
      treated by antivascular endothelial growth factor therapy.
PG  - 225-30
LID - 10.2147/OPTH.S22991 [doi]
AB  - OBJECTIVE: To report a good clinical outcome in a patient with bilateral 
      choroidal neovascularization (CNV) associated with optic nerve head drusen (ONHD) 
      treated with intravitreal ranibizumab injection. METHODS: A 12-year-old girl was 
      referred for loss of right eye vision detected in a routine check-up. 
      Best-corrected visual acuity (BCVA) was hand movements in the right eye and 0.9 
      in the left eye. Funduscopy revealed the presence of superficial and buried 
      bilateral ONHD, which was confirmed by ultrasonography and computed tomography, 
      and the study was completed with perimetry. The presence of bilateral CNV, active 
      in the right eye, was observed and subsequently confirmed using fluorescein 
      angiography and optical coherence tomography. RESULTS: Treatment with two 
      consecutive injections of intravitreal ranibizumab resulted in inactivation of 
      the neovascular membrane with subretinal fluid reabsorption and improved right 
      eye BCVA. After 12 months' follow-up, this was 20/60 and stable. CONCLUSION: 
      Although there are no published studies of safety in children, antiangiogenic 
      therapy for CNV secondary to ONHD may be useful and safe. A search of the 
      literature produced only one previously reported case of ONHD-associated CNV 
      treated with antivascular endothelial growth factor alone.
FAU - Delas, Barbara
AU  - Delas B
AD  - Ophthalmology Service, Hospital de Terrassa, Barcelona, Spain.
FAU - Almudi, Lorena
AU  - Almudi L
FAU - Carreras, Anabel
AU  - Carreras A
FAU - Asaad, Mouafk
AU  - Asaad M
LA  - eng
PT  - Case Reports
DEP - 20120213
PL  - New Zealand
TA  - Clin Ophthalmol
JT  - Clinical ophthalmology (Auckland, N.Z.)
JID - 101321512
PMC - PMC3284202
OTO - NOTNLM
OT  - anti-vegf
OT  - children
OT  - neovascularisation
OT  - optic nerve head drusen
EDAT- 2012/03/01 06:00
MHDA- 2012/03/01 06:01
PMCR- 2012/02/13
CRDT- 2012/02/28 06:00
PHST- 2012/02/28 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2012/03/01 06:01 [medline]
PHST- 2012/02/13 00:00 [pmc-release]
AID - opth-6-225 [pii]
AID - 10.2147/OPTH.S22991 [doi]
PST - ppublish
SO  - Clin Ophthalmol. 2012;6:225-30. doi: 10.2147/OPTH.S22991. Epub 2012 Feb 13.