PMID- 22368690
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1757-790X (Electronic)
IS  - 1757-790X (Linking)
VI  - 2010
DP  - 2010
TI  - A case of idiopathic hypertrophic cranial pachymeningitis presenting high values 
      of matrix metalloproteinase.
LID - bcr06.2009.2016 [pii]
LID - 10.1136/bcr.06.2009.2016 [doi]
AB  - This report concerns a 53-year-old male patient with idiopathic hypertrophic 
      cranial pachymeningitis who presented with multiple cranial nerve palsies (I, II, 
      III, IV, V, VI). Brain magnetic resonance imaging showed diffuse thickening and 
      gadolinium enhancement of the cerebral dura mater. A biopsy of the cerebral dura 
      mater showed granulomatous vasculitis with histiocyte infiltration. Although both 
      the serum rheumatoid factor (RF) and matrix metalloproteinase-3 (MMP-3) were 
      high, the patient showed no signs of arthritis. He was anti-cyclic citrullinated 
      peptide antibody negative, which makes the presence of comorbid chronic 
      rheumatoid arthritis (RA) unlikely. The aetiology of the pachymeningitis was 
      unknown, which led to the diagnosis of idiopathic hypertrophic cranial 
      pachymeningitis. Steroid pulse therapy successfully diminished the patient's 
      pachymeningitis and lowered both RF and MMP-3. High values of RF suggest the 
      possible involvement of an autoimmune mechanism, and the MMP value may be an 
      important indicator of the aetiology of pachymeningitis with granulomatous 
      vasculitis.
FAU - Nakamagoe, Kiyotaka
AU  - Nakamagoe K
AD  - Department of Neurology, Institute of Clinical Medicine, University of Tsukuba, 
      Tennodai 1-1-1, Tsukuba, Ibaraki, 305-8575, Japan.
FAU - Hosaka, Ai
AU  - Hosaka A
FAU - Kondo, Yuzuru
AU  - Kondo Y
FAU - Ishikawa, Eiichi
AU  - Ishikawa E
FAU - Tamaoka, Akira
AU  - Tamaoka A
LA  - eng
PT  - Journal Article
DEP - 20100225
PL  - England
TA  - BMJ Case Rep
JT  - BMJ case reports
JID - 101526291
PMC - PMC3027825
EDAT- 2010/01/01 00:00
MHDA- 2010/01/01 00:01
PMCR- 2012/02/25
CRDT- 2012/02/28 06:00
PHST- 2012/02/28 06:00 [entrez]
PHST- 2010/01/01 00:00 [pubmed]
PHST- 2010/01/01 00:01 [medline]
PHST- 2012/02/25 00:00 [pmc-release]
AID - bcr06.2009.2016 [pii]
AID - 10.1136/bcr.06.2009.2016 [doi]
PST - ppublish
SO  - BMJ Case Rep. 2010;2010:bcr06.2009.2016. doi: 10.1136/bcr.06.2009.2016. Epub 2010 
      Feb 25.