PMID- 223689
OWN - NLM
STAT- MEDLINE
DCOM- 19791024
LR  - 20081008
IS  - 0365-9615 (Print)
IS  - 0365-9615 (Linking)
VI  - 88
IP  - 7
DP  - 1979 Jul
TI  - [Carbohydrate metabolism enzymatic activity and its alteration under the 
      influence of thyroid hormone during tumor growth].
PG  - 71-4
AB  - The activity of hexokinase (HK), its isoenzymes, glucose-6-phosphatase and 
      glucose-6-phosphate dehydrogenase, and the triiodothyronine (T3) effect on this 
      activity in the liver tissue of mice bearing transplantable hepatoma 22a were 
      studied in different periods of the tumor growtn. It was shown that alterations 
      in the activity of the enzymes in the liver of tumor-bearing mice occurred 
      already in the presence of a small tumor. More profound alterations in the 
      activity of all enzymes studied, apart from those in the enzymatic pattern of HK, 
      could be observed starting from day 21after the tumor transplantation. In the 
      initial stages of the hepatoma growth the activity of the test enzymes in the 
      liver was regulated by thyroid hormone. The effect of Ta on the activity of the 
      enzymes in the host liver was gradually lost in the course of the tumor growth.
FAU - Teras, L E
AU  - Teras LE
LA  - rus
PT  - English Abstract
PT  - Journal Article
TT  - Aktivnost' fermentov uglevodnogo obmena i ee izmenenie pod vliianiem tireoidnogo 
      gormona pri opukholevom roste.
PL  - Russia (Federation)
TA  - Biull Eksp Biol Med
JT  - Biulleten' eksperimental'noi biologii i meditsiny
JID - 0370627
RN  - 0 (Isoenzymes)
RN  - 0 (Thyroid Hormones)
RN  - EC 1.1.1.49 (Glucosephosphate Dehydrogenase)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 3.1.3.9 (Glucose-6-Phosphatase)
SB  - IM
MH  - Animals
MH  - *Carbohydrate Metabolism
MH  - Enzyme Activation/drug effects
MH  - Glucose-6-Phosphatase/metabolism
MH  - Glucosephosphate Dehydrogenase/metabolism
MH  - Hexokinase/metabolism
MH  - Isoenzymes/metabolism
MH  - Liver/enzymology
MH  - Liver Neoplasms, Experimental/*enzymology
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Neoplasm Transplantation
MH  - Thyroid Hormones/*pharmacology
MH  - Time Factors
EDAT- 1979/07/01 00:00
MHDA- 1979/07/01 00:01
CRDT- 1979/07/01 00:00
PHST- 1979/07/01 00:00 [pubmed]
PHST- 1979/07/01 00:01 [medline]
PHST- 1979/07/01 00:00 [entrez]
PST - ppublish
SO  - Biull Eksp Biol Med. 1979 Jul;88(7):71-4.