PMID- 22369788
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20220321
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 73
IP  - 5
DP  - 2012 May
TI  - Association of tumor necrosis factor-alpha gene promoter polymorphisms (-308G/A, 
      -238G/A) with recurrent spontaneous abortion: a meta-analysis.
PG  - 574-9
LID - 10.1016/j.humimm.2012.01.008 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) gene promoter polymorphisms (-308G/A, -238G/A) 
      have been associated with increased recurrent spontaneous abortion (RSA) risk, 
      but the results of published articles are controversial. Hence, a meta-analysis 
      was performed to assess the effect of TNF-alpha -308G/A, -238G/A polymorphisms on RSA 
      risk. Heterogeneity testing and sensitivity analysis were performed using RevMan 
      5.0 software. Publication bias was assessed by the funnel plot method and 
      modified Egger's linear regression test. In 12 studies for the TNF-alpha -308G/A 
      polymorphism, the summary odds ratio (OR) with the corresponding 95% confidence 
      interval (95% CI) was 1.04 (95% CI: 0.86, 1.26) under a fixed-effect model in the 
      overall population. In 5 studies for the TNF-alpha -238G/A polymorphism, the summary 
      OR with the corresponding 95% CI was 1.11 (95% CI: 0.60, 2.03) under a 
      random-effect model in the overall population. We could not identify the sources 
      of heterogeneity for TNF-alpha -238G/A. In addition, no evidence of publication bias 
      was detected. The results of this meta-analysis indicate that TNF-alpha -308G/A, 
      -238G/A polymorphisms are not significantly associated with the risk of RSA in 
      the overall population. However, more convincing evidence is required to draw a 
      solid conclusion on the relation between the TNF-alpha -238G/A polymorphism and the 
      risk of RSA.
CI  - Copyright (c) 2012 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Zhang, Bingzhen
AU  - Zhang B
AD  - Department of Epidemiology, Health Statistics, School of Public Health, Shandong 
      University, Jinan, China.
FAU - Liu, Tiecheng
AU  - Liu T
FAU - Wang, Zhiping
AU  - Wang Z
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20120214
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Abortion, Habitual/*genetics
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
MH  - Pregnancy
MH  - Promoter Regions, Genetic
MH  - Risk
MH  - *Software
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2012/03/01 06:00
MHDA- 2013/01/19 06:00
CRDT- 2012/02/29 06:00
PHST- 2011/08/11 00:00 [received]
PHST- 2012/01/12 00:00 [revised]
PHST- 2012/01/24 00:00 [accepted]
PHST- 2012/02/29 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - S0198-8859(12)00018-3 [pii]
AID - 10.1016/j.humimm.2012.01.008 [doi]
PST - ppublish
SO  - Hum Immunol. 2012 May;73(5):574-9. doi: 10.1016/j.humimm.2012.01.008. Epub 2012 
      Feb 14.