PMID- 22370533
OWN - NLM
STAT- MEDLINE
DCOM- 20120716
LR  - 20161125
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 33
IP  - 1
DP  - 2012 Jan-Feb
TI  - Total serum IgE levels and atopic status in patients with sarcoidosis.
PG  - 90-4
LID - 10.2500/aap.2012.33.3491 [doi]
AB  - To date, two studies have reported lower total serum immunoglobulin E (IgE) 
      levels and lower prevalence of atopy in patients with sarcoidosis compared with 
      healthy subjects. However, those reports did not consider age or gender 
      differences between cases and controls. In addition, the association between 
      total serum IgE levels and clinical manifestations of sarcoidosis has not been 
      clarified. This study assessed total serum IgE levels and prevalence of atopy in 
      patients with sarcoidosis after taking age and sex differences into account and 
      evaluated associations between total serum IgE levels and clinical manifestations 
      of sarcoidosis. Total serum IgE levels and prevalence of atopy on initial visits 
      were compared between 189 patients with sarcoidosis and 378 age- and sex-matched 
      controls. Associations between total serum IgE levels and involvement of each 
      affected organ were evaluated. Changes in total serum IgE levels during the 
      clinical course of sarcoidosis were also evaluated. Total serum IgE levels were 
      significantly lower in patients with sarcoidosis than in controls, independent of 
      atopic status (atopic subjects, p = 0.025; nonatopic subjects, p < 0.001). Total 
      serum IgE levels did not differ according to the involvement of different organs. 
      Total serum IgE levels decreased further, albeit only slightly, after disease 
      remission (p < 0.001). Increased susceptibility to sarcoidosis may be 
      attributable to several underlying genetic or environmental factors that result 
      in lower total serum IgE levels.
FAU - Hattori, Takeshi
AU  - Hattori T
AD  - First Department of Medicine, Hokkaido University School of Medicine, Hokkaido 
      University Hospital, Sapporo, Hokkaido, Japan.
FAU - Konno, Satoshi
AU  - Konno S
FAU - Shigemura, Masahiko
AU  - Shigemura M
FAU - Matsuno, Kazuhiko
AU  - Matsuno K
FAU - Shimizu, Chikara
AU  - Shimizu C
FAU - Shigehara, Katsunori
AU  - Shigehara K
FAU - Shijubo, Noriharu
AU  - Shijubo N
FAU - Hizawa, Nobuyuki
AU  - Hizawa N
FAU - Yamaguchi, Etsuro
AU  - Yamaguchi E
FAU - Nishimura, Masaharu
AU  - Nishimura M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Disease Progression
MH  - Eye
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*diagnosis/*epidemiology/immunology
MH  - Immunoglobulin E/*blood/immunology
MH  - Lung/diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Radiography
MH  - Sarcoidosis/*diagnosis/*epidemiology/immunology
MH  - Young Adult
EDAT- 2012/03/01 06:00
MHDA- 2012/07/17 06:00
CRDT- 2012/02/29 06:00
PHST- 2012/02/29 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2012/07/17 06:00 [medline]
AID - 10.2500/aap.2012.33.3491 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2012 Jan-Feb;33(1):90-4. doi: 10.2500/aap.2012.33.3491.