PMID- 22371754
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Print)
IS  - 1734-1922 (Linking)
VI  - 6
IP  - 2
DP  - 2010 Apr 30
TI  - Serum proteomic profile analysis for endometrial carcinoma detection with 
      MALDI-TOF MS.
PG  - 245-52
LID - 10.5114/aoms.2010.13903 [doi]
AB  - INTRODUCTION: Endometrial carcinoma is the one of the leading causes of terminal 
      cancer death in women, and the best way to solve it is through an early 
      diagnosis. Serum proteomic profiling is a promising approach to classify disease 
      versus normal and matrix-assisted laser desorption/ionization time of flight mass 
      spectrometry (MALDI-TOF). This analysis is a new potential tool for the diagnosis 
      of human diseases. The objective of our study was to assess the feasibility of 
      mass spectrometry, based on serum proteomic pattern for the discrimination of 
      endometrial carcinoma patients from healthy control patients. MATERIAL AND 
      METHODS: By using 30 pre-operative endometrial carcinoma serum samples and 30 
      healthy controls, we generated MALDI-TOF protein profiles, established the serum 
      detection model, and analyzed the data. Furthermore, we validated the data and 
      got the total sensitivity (97.6%) and specificity (100%), which could classify 
      all the samples well and demonstrated the high, significant separation ability. 
      RESULTS: Our results indicated that high sensitivity and specificity classify 
      endometrial carcinoma by the serum detection model and showed the potential 
      usefulness of serum protein profiles. CONCLUSIONS: From these results, we could 
      tell that MALDI-TOF MS is a potential tool for diagnosing diseases by the use of 
      serum samples and will be widely used in the future for clinical work.
FAU - Qiu, Feng
AU  - Qiu F
AD  - Department of Clinical Biochemistry, Chinese PLA General Hospital, Beijing, 
      China.
FAU - Gao, Yan H
AU  - Gao YH
FAU - Jiang, Chao G
AU  - Jiang CG
FAU - Tian, Ya P
AU  - Tian YP
FAU - Zhang, Xue J
AU  - Zhang XJ
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC3281347
OTO - NOTNLM
OT  - serum proteomic analysis MALDI-TOF endometrial carcinoma serum detection model
EDAT- 2010/04/30 00:00
MHDA- 2010/04/30 00:01
PMCR- 2010/04/30
CRDT- 2012/02/29 06:00
PHST- 2009/05/19 00:00 [received]
PHST- 2009/06/21 00:00 [revised]
PHST- 2009/07/18 00:00 [accepted]
PHST- 2012/02/29 06:00 [entrez]
PHST- 2010/04/30 00:00 [pubmed]
PHST- 2010/04/30 00:01 [medline]
PHST- 2010/04/30 00:00 [pmc-release]
AID - 14655 [pii]
AID - 10.5114/aoms.2010.13903 [doi]
PST - ppublish
SO  - Arch Med Sci. 2010 Apr 30;6(2):245-52. doi: 10.5114/aoms.2010.13903.