PMID- 22372364
OWN - NLM
STAT- MEDLINE
DCOM- 20120313
LR  - 20190816
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 58
IP  - 1-2
DP  - 2012
TI  - Human Duffy blood group alloantigen system influences the measurement of monocyte 
      chemoattractant protein-1 (MCP-1) in serum but not in plasma.
PG  - 185-8
AB  - BACKGROUND: We explored whether the Asp42Gly polymorphism (rs12075) in the DARC 
      gene represents a confounding factor in the interpretation of monocyte 
      chemoattractant protein-1 (MCP-1) concentration in circulating blood. METHODS: 
      MCP-1 concentration in serum and plasma were measured in 278 healthy Caucasian 
      participants who are representative of our geographic area. The rs12075 genotype 
      distribution was also assessed in this population. RESULTS: Plasma MCP-1 
      concentration did not vary among the rs12075 polymorphism derived genotypes [in 
      pg/mL, AA: 171.9 (100.2 - 287.2), AG: 178.9 (105.1 - 326.4) and GG: 173.7 (94.4 - 
      405.7)]. However, there were significant increases in serum MCP-1 related to the 
      presence of the A allele [in pg/mL, AA: 334.6 (180.4 - 756.4), AG: 299.1 (166.1 - 
      634.9) and GG: 249.1 (149.3 - 578.1)]. CONCLUSIONS: These findings limit the 
      value of circulating MCP-1 as a biomarker and apparently indicate a 
      pathophysiological role for silent chemokine receptors.
FAU - Aragones, Gerard
AU  - Aragones G
AD  - Centre de Recerca Biomedica, Universitat Rovira i Virgili, Hospital Universitari 
      de Sant Joan, IISPV, Reus, Spain.
FAU - Ercilla, Amaia
AU  - Ercilla A
FAU - Barreda, Maria
AU  - Barreda M
FAU - Rull, Anna
AU  - Rull A
FAU - Beltran-Debon, Raul
AU  - Beltran-Debon R
FAU - Rodriguez-Gallego, Esther
AU  - Rodriguez-Gallego E
FAU - Alonso-Villaverde, Carlos
AU  - Alonso-Villaverde C
FAU - Camps, Jordi
AU  - Camps J
FAU - Joven, Jorge
AU  - Joven J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0 (ACKR1 protein, human)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Duffy Blood-Group System)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Chemokine CCL2/*blood
MH  - *Duffy Blood-Group System/genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Plasma
MH  - Polymorphism, Single Nucleotide
MH  - Receptors, Cell Surface/genetics
MH  - Serum
EDAT- 2012/03/01 06:00
MHDA- 2012/03/14 06:00
CRDT- 2012/03/01 06:00
PHST- 2012/03/01 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2012/03/14 06:00 [medline]
PST - ppublish
SO  - Clin Lab. 2012;58(1-2):185-8.