PMID- 22372998
OWN - NLM
STAT- MEDLINE
DCOM- 20120718
LR  - 20141120
IS  - 1365-2796 (Electronic)
IS  - 0954-6820 (Linking)
VI  - 271
IP  - 6
DP  - 2012 Jun
TI  - Can persistent organic pollutants and plastic-associated chemicals cause 
      cardiovascular disease?
PG  - 537-53
LID - 10.1111/j.1365-2796.2012.02536.x [doi]
AB  - During the last decade, associations between persistent organic pollutants 
      (POPs), such as polychlorinated biphenyls, dioxins and pesticides, and 
      cardiovascular (CV) risk factors and overt CV disease (CVD) have been reported in 
      humans. Recently, associations between plastic-associated chemicals (PACs), such 
      as bisphenol A and phthalates, and CVD have also begun to emerge. Several 
      approaches to evaluating such associations have been used: accidents with a high 
      level of exposure, occupational exposure studies, geographical studies of 
      subjects living near a contaminated area and traditional case-control or cohort 
      studies with measurements of circulating levels of different environmental 
      contaminants in the general population. Exposure to POPs has consistently been 
      associated with diabetes using all the approaches described above, including 
      prospective studies. The evidence regarding associations between exposure to POPs 
      and other CV risk factors, such as hypertension, obesity and lipids, is less 
      strong and is mainly based on cross-sectional data. Associations between overt 
      CVD and POPs have been reported using all the above approaches, but prospective 
      data from population-based studies are still lacking to provide firm evidence of 
      an important and independent role of POP exposure in the pathogenesis of CVD. 
      Nevertheless, taken together, current evidence suggests that further longitudinal 
      and experimental studies should be conducted to investigate the effect of 
      exposure to both POPs and PACs, such as bisphenol A and phthalates.
CI  - (c) 2012 The Association for the Publication of the Journal of Internal Medicine.
FAU - Lind, L
AU  - Lind L
AD  - Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 
      lars.lind@medsci.uu.se
FAU - Lind, P M
AU  - Lind PM
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120330
PL  - England
TA  - J Intern Med
JT  - Journal of internal medicine
JID - 8904841
RN  - 0 (Air Pollutants, Occupational)
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hazardous Substances)
RN  - 0 (Pesticides)
RN  - 0 (Phenols)
RN  - 0 (Plastics)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - MLT3645I99 (bisphenol A)
SB  - IM
MH  - Air Pollutants, Occupational/adverse effects
MH  - Atherosclerosis/chemically induced
MH  - Benzhydryl Compounds
MH  - Cardiovascular Diseases/*chemically induced/epidemiology
MH  - Coronary Disease/chemically induced
MH  - Diabetes Complications/chemically induced
MH  - Diabetes Mellitus/chemically induced
MH  - Dioxins/adverse effects
MH  - Environmental Monitoring/methods
MH  - Environmental Pollutants/*adverse effects
MH  - Epidemiological Monitoring
MH  - Evidence-Based Medicine
MH  - Global Health
MH  - Hazardous Substances/*adverse effects
MH  - Humans
MH  - Peripheral Arterial Disease/chemically induced
MH  - Pesticides/*adverse effects
MH  - Phenols/adverse effects
MH  - Plastics/*adverse effects
MH  - Polychlorinated Biphenyls/*adverse effects
MH  - Risk Factors
MH  - Stroke/chemically induced
MH  - Sweden/epidemiology
EDAT- 2012/03/01 06:00
MHDA- 2012/07/19 06:00
CRDT- 2012/03/01 06:00
PHST- 2012/03/01 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2012/07/19 06:00 [medline]
AID - 10.1111/j.1365-2796.2012.02536.x [doi]
PST - ppublish
SO  - J Intern Med. 2012 Jun;271(6):537-53. doi: 10.1111/j.1365-2796.2012.02536.x. Epub 
      2012 Mar 30.