PMID- 22373801
OWN - NLM
STAT- MEDLINE
DCOM- 20120504
LR  - 20220411
IS  - 1214-6994 (Print)
IS  - 1214-6994 (Linking)
VI  - 113
IP  - 1
DP  - 2012
TI  - Lack of association between interleukin-18 -607 C/A gene polymorphism and 
      pulmonary tuberculosis in Zahedan, Southeast Iran.
PG  - 16-22
AB  - Interleukin-18 (IL-18) plays a critical role in immune response, contributing to 
      the pathogenesis and pathophysiology of infectious diseases. Polymorphisms in the 
      IL-18 genes are known to influence expression levels and may be associated with 
      outcome of infections. The objective of this study was to determine whether the 
      presence of IL-18 polymorphisms -607 A/C (rs1946518) was associated with 
      tuberculosis disease. We investigated the functional polymorphism of IL-18 
      (rs1946518) in 174 patients with pulmonary tuberculosis (PTB) and 177 healthy 
      subjects. Genotype analysis was done using tetra amplification refractory 
      mutation system-PCR (T-ARMS-PCR). The allelic and genotypic frequencies of the 
      IL-18 polymorphism did not differ significantly between PTB and the controls. Our 
      finding suggests that IL-18 polymorphism (rs1946518) may not be a risk factor for 
      susceptibility to tuberculosis in a sample of Iranian population. Further studies 
      are required to validate our findings.
FAU - Taheri, M
AU  - Taheri M
AD  - Cellular and Molecular Research Center, Zahedan University of Medical Sciences, 
      Zahedan, Iran.
FAU - Hashemi-Shahri, S M
AU  - Hashemi-Shahri SM
FAU - Hamzehnejadi, M
AU  - Hamzehnejadi M
FAU - Naderi, M
AU  - Naderi M
FAU - Moazeni-Roodi, A
AU  - Moazeni-Roodi A
FAU - Bahari, G
AU  - Bahari G
FAU - Hashemi, M
AU  - Hashemi M
LA  - eng
PT  - Journal Article
PL  - Czech Republic
TA  - Prague Med Rep
JT  - Prague medical report
JID - 101227436
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Tuberculosis, Pulmonary/*genetics
EDAT- 2012/03/01 06:00
MHDA- 2012/05/05 06:00
CRDT- 2012/03/01 06:00
PHST- 2012/03/01 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2012/05/05 06:00 [medline]
AID - PMR2012A0002 [pii]
AID - 10.14712/23362936.2015.33 [doi]
PST - ppublish
SO  - Prague Med Rep. 2012;113(1):16-22. doi: 10.14712/23362936.2015.33.