PMID- 22373961
OWN - NLM
STAT- MEDLINE
DCOM- 20120905
LR  - 20231104
IS  - 1873-7528 (Electronic)
IS  - 0149-7634 (Print)
IS  - 0149-7634 (Linking)
VI  - 36
IP  - 5
DP  - 2012 May
TI  - APP transgenic mice for modelling behavioural and psychological symptoms of 
      dementia (BPSD).
PG  - 1357-75
LID - 10.1016/j.neubiorev.2012.02.011 [doi]
AB  - The discovery of gene mutations responsible for autosomal dominant Alzheimer's 
      disease has enabled researchers to reproduce in transgenic mice several hallmarks 
      of this disorder, notably Abeta accumulation, though in most cases without 
      neurofibrillary tangles. Mice expressing mutated and wild-type APP as well as 
      C-terminal fragments of APP exhibit variations in exploratory activity 
      reminiscent of behavioural and psychological symptoms of Alzheimer dementia 
      (BPSD). In particular, open-field, spontaneous alternation, and elevated 
      plus-maze tasks as well as aggression are modified in several APP transgenic mice 
      relative to non-transgenic controls. However, depending on the precise murine 
      models, changes in open-field and elevated plus-maze exploration occur in either 
      direction, either increased or decreased relative to controls. It remains to be 
      determined which neurotransmitter changes are responsible for this variability, 
      in particular with respect to GABA, 5HT, and dopamine.
CI  - Copyright (c) 2012 Elsevier Ltd. All rights reserved.
FAU - Lalonde, R
AU  - Lalonde R
AD  - Departement de Psychologie, Faculte des Sciences, Universite de Rouen, 76821 
      Mont-Saint-Aignan Cedex, France. robert.lalonde@univ-rouen.fr
FAU - Fukuchi, K
AU  - Fukuchi K
FAU - Strazielle, C
AU  - Strazielle C
LA  - eng
GR  - R01 AG030399/AG/NIA NIH HHS/United States
GR  - R01 AG030399-04/AG/NIA NIH HHS/United States
GR  - AG030399/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120221
PL  - United States
TA  - Neurosci Biobehav Rev
JT  - Neuroscience and biobehavioral reviews
JID - 7806090
RN  - 0 (Amyloid beta-Protein Precursor)
SB  - IM
MH  - Amyloid beta-Protein Precursor/*genetics
MH  - Animals
MH  - Behavioral Symptoms/*genetics/*psychology
MH  - Dementia/*genetics/*psychology
MH  - *Disease Models, Animal
MH  - Humans
MH  - Mice
MH  - *Mice, Transgenic
MH  - Mutation
PMC - PMC3340431
MID - NIHMS366299
EDAT- 2012/03/01 06:00
MHDA- 2012/09/06 06:00
PMCR- 2013/05/01
CRDT- 2012/03/01 06:00
PHST- 2011/12/07 00:00 [received]
PHST- 2012/02/10 00:00 [revised]
PHST- 2012/02/13 00:00 [accepted]
PHST- 2012/03/01 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2012/09/06 06:00 [medline]
PHST- 2013/05/01 00:00 [pmc-release]
AID - S0149-7634(12)00037-1 [pii]
AID - 10.1016/j.neubiorev.2012.02.011 [doi]
PST - ppublish
SO  - Neurosci Biobehav Rev. 2012 May;36(5):1357-75. doi: 
      10.1016/j.neubiorev.2012.02.011. Epub 2012 Feb 21.