PMID- 22374415
OWN - NLM
STAT- MEDLINE
DCOM- 20120830
LR  - 20120507
IS  - 1096-0295 (Electronic)
IS  - 0273-2300 (Linking)
VI  - 63
IP  - 1
DP  - 2012 Jun
TI  - Guiding principles for the implementation of non-animal safety assessment 
      approaches for cosmetics: skin sensitisation.
PG  - 40-52
LID - 10.1016/j.yrtph.2012.02.007 [doi]
AB  - Characterisation of skin sensitisation potential is a key endpoint for the safety 
      assessment of cosmetic ingredients especially when significant dermal exposure to 
      an ingredient is expected. At present the mouse local lymph node assay (LLNA) 
      remains the 'gold standard' test method for this purpose however non-animal test 
      methods are under development that aim to replace the need for new animal test 
      data. COLIPA (the European Cosmetics Association) funds an extensive programme of 
      skin sensitisation research, method development and method evaluation and helped 
      coordinate the early evaluation of the three test methods currently undergoing 
      pre-validation. In May 2010, a COLIPA scientific meeting was held to analyse to 
      what extent skin sensitisation safety assessments for cosmetic ingredients can be 
      made in the absence of animal data. In order to propose guiding principles for 
      the application and further development of non-animal safety assessment 
      strategies it was evaluated how and when non-animal test methods, predictions 
      based on physico-chemical properties (including in silico tools), threshold 
      concepts and weight-of-evidence based hazard characterisation could be used to 
      enable safety decisions. Generation and assessment of potency information from 
      alternative tools which at present is predominantly derived from the LLNA is 
      considered the future key research area.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Goebel, Carsten
AU  - Goebel C
AD  - Procter & Gamble, Berliner Allee 65, 64274 Darmstadt, Germany.
FAU - Aeby, Pierre
AU  - Aeby P
FAU - Ade, Nadege
AU  - Ade N
FAU - Alepee, Nathalie
AU  - Alepee N
FAU - Aptula, Aynur
AU  - Aptula A
FAU - Araki, Daisuke
AU  - Araki D
FAU - Dufour, Eric
AU  - Dufour E
FAU - Gilmour, Nicola
AU  - Gilmour N
FAU - Hibatallah, Jalila
AU  - Hibatallah J
FAU - Keller, Detlef
AU  - Keller D
FAU - Kern, Petra
AU  - Kern P
FAU - Kirst, Annette
AU  - Kirst A
FAU - Marrec-Fairley, Monique
AU  - Marrec-Fairley M
FAU - Maxwell, Gavin
AU  - Maxwell G
FAU - Rowland, Joanna
AU  - Rowland J
FAU - Safford, Bob
AU  - Safford B
FAU - Schellauf, Florian
AU  - Schellauf F
FAU - Schepky, Andreas
AU  - Schepky A
FAU - Seaman, Chris
AU  - Seaman C
FAU - Teichert, Thomas
AU  - Teichert T
FAU - Tessier, Nicolas
AU  - Tessier N
FAU - Teissier, Silvia
AU  - Teissier S
FAU - Weltzien, Hans Ulrich
AU  - Weltzien HU
FAU - Winkler, Petra
AU  - Winkler P
FAU - Scheel, Julia
AU  - Scheel J
LA  - eng
PT  - Journal Article
DEP - 20120221
PL  - Netherlands
TA  - Regul Toxicol Pharmacol
JT  - Regulatory toxicology and pharmacology : RTP
JID - 8214983
RN  - 0 (Allergens)
RN  - 0 (Cosmetics)
SB  - IM
MH  - Allergens/*toxicity
MH  - *Animal Testing Alternatives
MH  - *Consumer Product Safety
MH  - Cosmetics/*toxicity
MH  - Hypersensitivity/*etiology
MH  - Risk Assessment/methods
MH  - Skin/*drug effects/immunology
EDAT- 2012/03/01 06:00
MHDA- 2012/08/31 06:00
CRDT- 2012/03/01 06:00
PHST- 2011/02/25 00:00 [received]
PHST- 2012/02/10 00:00 [revised]
PHST- 2012/02/11 00:00 [accepted]
PHST- 2012/03/01 06:00 [entrez]
PHST- 2012/03/01 06:00 [pubmed]
PHST- 2012/08/31 06:00 [medline]
AID - S0273-2300(12)00033-5 [pii]
AID - 10.1016/j.yrtph.2012.02.007 [doi]
PST - ppublish
SO  - Regul Toxicol Pharmacol. 2012 Jun;63(1):40-52. doi: 10.1016/j.yrtph.2012.02.007. 
      Epub 2012 Feb 21.