PMID- 22377524
OWN - NLM
STAT- MEDLINE
DCOM- 20120626
LR  - 20120301
IS  - 1440-1592 (Electronic)
IS  - 1323-8930 (Linking)
VI  - 61
IP  - 1
DP  - 2012 Mar
TI  - Cytokine profiles in Japanese patients with chronic rhinosinusitis.
PG  - 115-22
LID - 10.2332/allergolint.10-OA-0290 [doi]
AB  - BACKGROUND: Chronic rhinosinusitis (CRS) is classified in CRS without nasal polyp 
      (CRSsNP) and CRS with nasal polyp (CRSwNP) in western countries, whereas this 
      classification was not common so far in Japan. Studying inflammatory mediators in 
      clearly defined disease subgroups may lead to a better differentiation of chronic 
      sinus diseases. METHODS: Homogenates of sinonasal mucosal tissue from 14 
      controls, 9 CRSsNP patients, and 19 CRSwNP patients were assayed for transforming 
      growth factor (TGF)-beta, interleukin (IL)-5, immunoglobulin E (IgE), Staphylococcus 
      enterotoxin (SAE)-IgE, eosinophil-catioic protein (ECP), myeloperoxidase (MPO), 
      IL-1beta, IL-6, and IL-8 by enzyme-linked immunosorbent assay or UNICAP system. 
      RESULTS: CRSwNP had significantly higher levels of IL-5, IgE, SAE-IgE, and ECP 
      compared with CRSsNP and controls. CRSsNP was characterized by high levels of 
      TGF-beta, while CRSwNP showed a Th2 polarization and lower levels of TGF-beta. 
      Especially, in CRSwNP samples, 68.4% were eosinophilic (ECP/MPO ratio >1), and 
      52.6% were SAE-IgE positive. On the other hand, in 9 CRSsNP patients, 
      eosinophilic or SAE-IgE positive sample was only one sample respectively. 
      Additionally, 31.6% of CRSwNP were asthmatic patients, while none of CRSsNP 
      patient was suffering from bronchial asthma. CONCLUSIONS: This study is thought 
      to be the first one that showed the cytokine profiles in Japanese CRSs/wNP 
      similar to those of European CRS. Based on mediator profiles, we suggest that 
      CRSsNP and CRSwNP are distinct disease entities within the group of chronic sinus 
      diseases.
FAU - Sejima, Takayuki
AU  - Sejima T
AD  - Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent 
      University Hospital, Ghent, Belgium. t-sejima@jichi.ac.jp
FAU - Holtappels, Gabriele
AU  - Holtappels G
FAU - Kikuchi, Hisashi
AU  - Kikuchi H
FAU - Imayoshi, Shoichiro
AU  - Imayoshi S
FAU - Ichimura, Keiichi
AU  - Ichimura K
FAU - Bachert, Claus
AU  - Bachert C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Allergol Int
JT  - Allergology international : official journal of the Japanese Society of 
      Allergology
JID - 9616296
RN  - 0 (Cytokines)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chronic Disease
MH  - Cytokines/*metabolism
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Nasal Polyps/immunology/metabolism
MH  - Rhinitis/*immunology/metabolism/pathology
MH  - Sinusitis/*immunology/metabolism/pathology
MH  - Young Adult
EDAT- 2012/03/02 06:00
MHDA- 2012/06/27 06:00
CRDT- 2012/03/02 06:00
PHST- 2010/11/08 00:00 [received]
PHST- 2011/07/17 00:00 [accepted]
PHST- 2012/03/02 06:00 [entrez]
PHST- 2012/03/02 06:00 [pubmed]
PHST- 2012/06/27 06:00 [medline]
AID - S1323-8930(15)30201-X [pii]
AID - 10.2332/allergolint.10-OA-0290 [doi]
PST - ppublish
SO  - Allergol Int. 2012 Mar;61(1):115-22. doi: 10.2332/allergolint.10-OA-0290.