PMID- 22377681
OWN - NLM
STAT- MEDLINE
DCOM- 20120806
LR  - 20131121
IS  - 1559-064X (Electronic)
IS  - 1559-0631 (Linking)
VI  - 22
IP  - 3
DP  - 2012 May-Jun
TI  - Levels and predictors of airborne and internal exposure to manganese and iron 
      among welders.
PG  - 291-8
LID - 10.1038/jes.2012.9 [doi]
AB  - We investigated airborne and internal exposure to manganese (Mn) and iron (Fe) 
      among welders. Personal sampling of welding fumes was carried out in 241 welders 
      during a shift. Metals were determined by inductively coupled plasma mass 
      spectrometry. Mn in blood (MnB) was analyzed by graphite furnace atom absorption 
      spectrometry. Determinants of exposure levels were estimated with multiple 
      regression models. Respirable Mn was measured with a median of 62 (inter-quartile 
      range (IQR) 8.4-320) mug/m(3) and correlated with Fe (r=0.92, 95% CI 0.90-0.94). 
      Inhalable Mn was measured with similar concentrations (IQR 10-340 mug/m(3)). About 
      70% of the variance of Mn and Fe could be explained, mainly by the welding 
      process. Ventilation decreased exposure to Fe and Mn significantly. Median 
      concentrations of MnB and serum ferritin (SF) were 10.30 mug/l (IQR 
      8.33-13.15 mug/l) and 131 mug/l (IQR 76-240 mug/l), respectively. Few welders were 
      presented with low iron stores, and MnB and SF were not correlated (r=0.07, 95% 
      CI -0.05 to 0.20). Regression models revealed a significant association of the 
      parent metal with MnB and SF, but a low fraction of variance was explained by 
      exposure-related factors. Mn is mainly respirable in welding fumes. Airborne Mn 
      and Fe influenced MnB and SF, respectively, in welders. This indicates an effect 
      on the biological regulation of both metals. Mn and Fe were strongly correlated, 
      whereas MnB and SF were not, likely due to higher iron stores among welders.
FAU - Pesch, Beate
AU  - Pesch B
AD  - Center of Epidemiology, Institute for Prevention and Occupational Medicine of the 
      German Social Accident Insurance, Institute of the Ruhr-Universitat Bochum (IPA), 
      Burkle-de-la-Camp-Platz, Bochum, Germany. pesch@ipa-dguv.de
FAU - Weiss, Tobias
AU  - Weiss T
FAU - Kendzia, Benjamin
AU  - Kendzia B
FAU - Henry, Jana
AU  - Henry J
FAU - Lehnert, Martin
AU  - Lehnert M
FAU - Lotz, Anne
AU  - Lotz A
FAU - Heinze, Evelyn
AU  - Heinze E
FAU - Kafferlein, Heiko Udo
AU  - Kafferlein HU
FAU - Van Gelder, Rainer
AU  - Van Gelder R
FAU - Berges, Markus
AU  - Berges M
FAU - Hahn, Jens-Uwe
AU  - Hahn JU
FAU - Mattenklott, Markus
AU  - Mattenklott M
FAU - Punkenburg, Ewald
AU  - Punkenburg E
FAU - Hartwig, Andrea
AU  - Hartwig A
FAU - Bruning, Thomas
AU  - Bruning T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120229
PL  - United States
TA  - J Expo Sci Environ Epidemiol
JT  - Journal of exposure science & environmental epidemiology
JID - 101262796
RN  - 0 (Air Pollutants, Occupational)
RN  - 42Z2K6ZL8P (Manganese)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Air Pollutants, Occupational/*toxicity
MH  - Humans
MH  - Inhalation Exposure
MH  - Iron/*toxicity
MH  - Manganese/*toxicity
MH  - Middle Aged
MH  - *Occupational Exposure
MH  - *Welding
EDAT- 2012/03/02 06:00
MHDA- 2012/08/07 06:00
CRDT- 2012/03/02 06:00
PHST- 2012/03/02 06:00 [entrez]
PHST- 2012/03/02 06:00 [pubmed]
PHST- 2012/08/07 06:00 [medline]
AID - jes20129 [pii]
AID - 10.1038/jes.2012.9 [doi]
PST - ppublish
SO  - J Expo Sci Environ Epidemiol. 2012 May-Jun;22(3):291-8. doi: 10.1038/jes.2012.9. 
      Epub 2012 Feb 29.