PMID- 22377714
OWN - NLM
STAT- MEDLINE
DCOM- 20120813
LR  - 20161125
IS  - 1435-232X (Electronic)
IS  - 1434-5161 (Linking)
VI  - 57
IP  - 4
DP  - 2012 Apr
TI  - Impact of common type 2 diabetes risk gene variants on future type 2 diabetes in 
      the non-diabetic population in Korea.
PG  - 265-8
LID - 10.1038/jhg.2012.16 [doi]
AB  - We prospectively examined the association between type 2 diabetes mellitus (T2DM) 
      progression and common T2DM-risk gene variants in 870 non-diabetic participants 
      in a Chungju Metabolic Disease Cohort Study in Korea. We genotyped the following 
      six single nucleotide polymorphisms (SNPs): KCNQ1 (potassium voltage-gated 
      channel, KQT-like subfamily member 1) rs2237892, CDKAL1 (regulatory 
      subunit-associated protein 1-like 1) rs7554840, CDKN2A/B (cyclin-dependent kinase 
      inhibitor 2A/B) rs1081161, SCL30A8 (solute carrier family 30 member 8 gene) 
      rs13266634, TCF7L2 (transcription factor 7-like 2) rs7903146, and PPARG 
      (peroxisome proliferator activated receptor gamma) rs1801282. Anthropometric data 
      and metabolic parameters were obtained at baseline and year 4. Pancreatic beta cell 
      function was assessed by the homeostasis model assessment index of beta cells 
      (HOMA-beta). After 4 years, 137 subjects developed T2DM (15.7%). A significant 
      association was found in the variant of KCNQ1 rs2237892, whereas the SNPs of 
      CDKAL1, CDKN2A/B, SCL30A8, TCF7L2 and PPARG were not associated. The C-allele 
      carriers of KCNQ1 conferred a significantly increased risk for T2DM compared with 
      the T/T genotype, independently of clinical risk factors (odds ratio=2.61, 95% 
      confidence intervals=1.02-6.69, P=0.04). Although no differences were observed at 
      baseline among the KCNQ1 variants, HOMA-beta levels by year 4 were significantly 
      lower in the C-allele carriers after controlling for metabolic parameters. The 
      genetic variations in KCNQ1 are associated with future development of T2DM in 
      Koreans, which might be mediated by differences in insulin secretory function.
FAU - Park, Se Eun
AU  - Park SE
AD  - Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, 
      Sungkyunkwan University School of Medicine, Seoul, Korea.
FAU - Lee, Won Young
AU  - Lee WY
FAU - Oh, Ki Won
AU  - Oh KW
FAU - Baek, Ki Hyun
AU  - Baek KH
FAU - Yoon, Kun Ho
AU  - Yoon KH
FAU - Kang, Moo Il
AU  - Kang MI
FAU - Son, Ho Young
AU  - Son HY
FAU - Lee, Won Chul
AU  - Lee WC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120301
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
RN  - 0 (KCNQ1 Potassium Channel)
RN  - 0 (KCNQ1 protein, human)
RN  - 0 (PPAR gamma)
RN  - 0 (TCF7L2 protein, human)
RN  - 0 (Transcription Factor 7-Like 2 Protein)
RN  - EC 2.1.1.- (tRNA Methyltransferases)
RN  - EC 2.7.11.1 (Cyclin-Dependent Kinase 5)
RN  - EC 2.8.4.5 (CDKAL1 protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cyclin-Dependent Kinase 5/genetics
MH  - Cyclin-Dependent Kinase Inhibitor p16/genetics
MH  - Diabetes Mellitus, Type 2/epidemiology/*genetics/metabolism
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genetic Variation
MH  - Homeostasis
MH  - Humans
MH  - Insulin-Secreting Cells/metabolism/pathology
MH  - KCNQ1 Potassium Channel/*genetics
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - PPAR gamma/genetics
MH  - Polymorphism, Single Nucleotide
MH  - Prospective Studies
MH  - Republic of Korea/epidemiology
MH  - Risk Factors
MH  - Transcription Factor 7-Like 2 Protein/genetics
MH  - tRNA Methyltransferases
EDAT- 2012/03/02 06:00
MHDA- 2012/08/14 06:00
CRDT- 2012/03/02 06:00
PHST- 2012/03/02 06:00 [entrez]
PHST- 2012/03/02 06:00 [pubmed]
PHST- 2012/08/14 06:00 [medline]
AID - jhg201216 [pii]
AID - 10.1038/jhg.2012.16 [doi]
PST - ppublish
SO  - J Hum Genet. 2012 Apr;57(4):265-8. doi: 10.1038/jhg.2012.16. Epub 2012 Mar 1.