PMID- 22378538
OWN - NLM
STAT- MEDLINE
DCOM- 20120717
LR  - 20220409
IS  - 1521-4095 (Electronic)
IS  - 0935-9648 (Linking)
VI  - 24
IP  - 12
DP  - 2012 Mar 22
TI  - Mesoporous silica nanoparticles: synthesis, biocompatibility and drug delivery.
PG  - 1504-34
LID - 10.1002/adma.201104763 [doi]
AB  - In the past decade, mesoporous silica nanoparticles (MSNs) have attracted more 
      and more attention for their potential biomedical applications. With their 
      tailored mesoporous structure and high surface area, MSNs as drug delivery 
      systems (DDSs) show significant advantages over traditional drug nanocarriers. In 
      this review, we overview the recent progress in the synthesis of MSNs for drug 
      delivery applications. First, we provide an overview of synthesis strategies for 
      fabricating ordered MSNs and hollow/rattle-type MSNs. Then, the in vitro and in 
      vivo biocompatibility and biotranslocation of MSNs are discussed in relation to 
      their chemophysical properties including particle size, surface properties, 
      shape, and structure. The review also highlights the significant achievements in 
      drug delivery using mesoporous silica nanoparticles and their multifunctional 
      counterparts as drug carriers. In particular, the biological barriers for 
      nano-based targeted cancer therapy and MSN-based targeting strategies are 
      discussed. We conclude with our personal perspectives on the directions in which 
      future work in this field might be focused.
CI  - Copyright (c) 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Tang, Fangqiong
AU  - Tang F
AD  - Laboratory of Controllable Preparation and Application of Nanomaterials, 
      Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 
      Beijing, China . tangfq@mail.ipc.ac.cn
FAU - Li, Linlin
AU  - Li L
FAU - Chen, Dong
AU  - Chen D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20120229
PL  - Germany
TA  - Adv Mater
JT  - Advanced materials (Deerfield Beach, Fla.)
JID - 9885358
RN  - 0 (Biocompatible Materials)
RN  - 0 (Drug Carriers)
RN  - 7631-86-9 (Silicon Dioxide)
SB  - IM
MH  - Animals
MH  - Biocompatible Materials/adverse effects/*chemical synthesis/*chemistry
MH  - Drug Carriers/adverse effects/*chemical synthesis/*chemistry
MH  - Humans
MH  - Nanomedicine/*methods
MH  - Nanoparticles/adverse effects/*chemistry
MH  - Porosity
MH  - Silicon Dioxide/adverse effects/*chemical synthesis/*chemistry
EDAT- 2012/03/02 06:00
MHDA- 2012/07/18 06:00
CRDT- 2012/03/02 06:00
PHST- 2011/12/13 00:00 [received]
PHST- 2012/03/02 06:00 [entrez]
PHST- 2012/03/02 06:00 [pubmed]
PHST- 2012/07/18 06:00 [medline]
AID - 10.1002/adma.201104763 [doi]
PST - ppublish
SO  - Adv Mater. 2012 Mar 22;24(12):1504-34. doi: 10.1002/adma.201104763. Epub 2012 Feb 
      29.