PMID- 22380495
OWN - NLM
STAT- MEDLINE
DCOM- 20120403
LR  - 20220409
IS  - 0006-9248 (Print)
IS  - 0006-9248 (Linking)
VI  - 113
IP  - 1
DP  - 2012
TI  - Association of angiotensin converting enzyme gene (I/D) polymorphism with 
      hypertension and type 2 diabetes.
PG  - 14-8
AB  - OBJECTIVES: This study was conducted to determine the association of 
      insertion/deletion (I/D) polymorphism of the ACE gene in hypertensive and T2DM 
      subjects in Egyptian population. BACKGROUND: The deletion (D) allele of the 
      angiotensin-converting enzyme (ACE) gene has been studied in relation to 
      hypertension and type 2 diabetes mellitus (T2DM) with contradictory results which 
      might be due to ethnic and geographical variations. METHODS: A total of 85 
      subjects participated in this study; hypertension (Group 1); type 2 diabetes 
      mellitus (Group 2) and controls (Group 3). Written informed consent was obtained. 
      for each subject: age, sex, diabetes duration and the drugs used, blood pressure 
      (systolic and diastolic), and lipid profile. Genotyping was performed by 
      polymerase chain reaction (PCR). RESULTS: The frequency of DD genotype was 
      significantly higher in hypertensive (60 %) and diabetic patients (68 %) compared 
      to controls (33.3 %) (p=0.04, p=0.01 respectively). The DD genotype (vs DI and II 
      genotype) in the hypertensive and diabetic groups is associated with increased 
      risk of hypertension and/or diabetes. OR=3.00; 95%, Cl = 0.993-9.067; OR=4.250; 
      95%, Cl = 1.234-14.63 respectively). The D allele was more frequent in 
      hypertensive (77.5 %) and diabetic patients (82 %) compared to controls (52.4 %) 
      (p=0.004 and 0.002 respectively). The D allele (vs the I allele) is associated 
      with increased risk of hypertension and diabetes OR=3.13, 95%Cl=1.405-6.978; OR= 
      4.14, 95% CI= 1.615-10.622 respectively). CONCLUSION: The DD genotype and the D 
      allele are associated with hypertension and type 2 diabetes in Egyptian patients 
      (Tab. 5, Fig. 1, Ref. 32).
FAU - Zarouk, W A
AU  - Zarouk WA
AD  - Molecular Genetic and Enzymology Department, National Research Centre, Cairo, 
      Egypt. w_zarouk@yahoo.com
FAU - Hussein, I R
AU  - Hussein IR
FAU - Esmaeil, N N
AU  - Esmaeil NN
FAU - Raslan, H M
AU  - Raslan HM
FAU - Reheim, H A A
AU  - Reheim HA
FAU - Moguib, O
AU  - Moguib O
FAU - Emara, N A
AU  - Emara NA
FAU - Aly, A A
AU  - Aly AA
FAU - Hamed, M
AU  - Hamed M
LA  - eng
PT  - Journal Article
PL  - Slovakia
TA  - Bratisl Lek Listy
JT  - Bratislavske lekarske listy
JID - 0065324
RN  - EC 3.4.15.1 (Peptidyl-Dipeptidase A)
SB  - IM
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Hypertension/*genetics
MH  - Male
MH  - Middle Aged
MH  - Peptidyl-Dipeptidase A/*genetics
MH  - *Polymorphism, Genetic
EDAT- 2012/03/03 06:00
MHDA- 2012/04/04 06:00
CRDT- 2012/03/03 06:00
PHST- 2012/03/03 06:00 [entrez]
PHST- 2012/03/03 06:00 [pubmed]
PHST- 2012/04/04 06:00 [medline]
AID - 10.4149/bll_2012_003 [doi]
PST - ppublish
SO  - Bratisl Lek Listy. 2012;113(1):14-8. doi: 10.4149/bll_2012_003.