PMID- 22381024
OWN - NLM
STAT- MEDLINE
DCOM- 20121002
LR  - 20240418
IS  - 1097-6833 (Electronic)
IS  - 0022-3476 (Print)
IS  - 0022-3476 (Linking)
VI  - 161
IP  - 2
DP  - 2012 Aug
TI  - Role of carbohydrate modification in weight management among obese children: a 
      randomized clinical trial.
PG  - 320-7.e1
LID - 10.1016/j.jpeds.2012.01.041 [doi]
AB  - OBJECTIVE: To compare the effectiveness and safety of carbohydrate (CHO)-modified 
      diets with a standard portion-controlled (PC) diet in obese children. STUDY 
      DESIGN: Obese children (n=102) aged 7-12 years were randomly assigned to a 
      3-month intervention of a low-CHO (LC), reduced glycemic load (RGL), or standard 
      PC diet, along with weekly dietary counseling and biweekly group exercise. 
      Anthropometry, dietary adherence, and clinical measures were evaluated at 
      baseline and 3, 6, and 12 months. Analyses applied intention-to-treat 
      longitudinal mixed models. RESULTS: Eighty-five children (83%) completed the 
      12-month assessment. Daily caloric intake decreased from baseline to all time 
      points for all diet groups (P<.0001), although LC diet adherence was persistently 
      lower (P<.0002). At 3 months, body mass index z score was lower in all diet 
      groups (LC, -0.27 +/- 0.04; RGL, -0.20 +/- 0.04; PC, -0.21 +/- 0.04; P<.0001) and was 
      maintained at 6 months, with similar results for waist circumference and percent 
      body fat. At 12 months, participants in all diet groups had lower body mass index 
      z scores than at baseline (LC, -0.21 +/- 0.04; RGL, -0.28 +/- 0.04; PC, -0.31 +/- 0.04; 
      P<.0001), and lower percent body fat, but no reductions in waist circumference 
      were maintained. All diets demonstrated some improved clinical measures. 
      CONCLUSION: Diets with modified CHO intake were as effective as a PC diet for 
      weight management in obese children. However, the lower adherence to the LC diet 
      suggests that this regimen is more difficult for children to follow, particularly 
      in the long term.
CI  - Copyright (c) 2012 Mosby, Inc. All rights reserved.
FAU - Kirk, Shelley
AU  - Kirk S
AD  - Center for Better Health and Nutrition, The Heart Institute, Cincinnati 
      Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA. 
      shelley.kirk@cchmc.org
FAU - Brehm, Bonnie
AU  - Brehm B
FAU - Saelens, Brian E
AU  - Saelens BE
FAU - Woo, Jessica G
AU  - Woo JG
FAU - Kissel, Elizabeth
AU  - Kissel E
FAU - D'Alessio, David
AU  - D'Alessio D
FAU - Bolling, Christopher
AU  - Bolling C
FAU - Daniels, Stephen R
AU  - Daniels SR
LA  - eng
GR  - UL1 RR026314/RR/NCRR NIH HHS/United States
GR  - UL1 RR026314-01S2/RR/NCRR NIH HHS/United States
GR  - 5UL1RR026314-02/RR/NCRR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20120228
PL  - United States
TA  - J Pediatr
JT  - The Journal of pediatrics
JID - 0375410
RN  - 0 (Lipids)
SB  - IM
MH  - Body Mass Index
MH  - Child
MH  - *Diet, Carbohydrate-Restricted
MH  - Diet, Reducing
MH  - Energy Intake
MH  - Female
MH  - Glycemic Index
MH  - Humans
MH  - Lipids/blood
MH  - Male
MH  - Obesity/blood/*diet therapy
MH  - Patient Compliance
MH  - Weight Loss
PMC - PMC3406261
MID - NIHMS362087
COIS- The other authors declare no conflicts of interest.
EDAT- 2012/03/03 06:00
MHDA- 2012/10/04 06:00
PMCR- 2013/08/01
CRDT- 2012/03/03 06:00
PHST- 2011/09/08 00:00 [received]
PHST- 2011/12/05 00:00 [revised]
PHST- 2012/01/19 00:00 [accepted]
PHST- 2012/03/03 06:00 [entrez]
PHST- 2012/03/03 06:00 [pubmed]
PHST- 2012/10/04 06:00 [medline]
PHST- 2013/08/01 00:00 [pmc-release]
AID - S0022-3476(12)00099-6 [pii]
AID - 10.1016/j.jpeds.2012.01.041 [doi]
PST - ppublish
SO  - J Pediatr. 2012 Aug;161(2):320-7.e1. doi: 10.1016/j.jpeds.2012.01.041. Epub 2012 
      Feb 28.