PMID- 22382400
OWN - NLM
STAT- MEDLINE
DCOM- 20130409
LR  - 20211021
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Print)
IS  - 0937-4477 (Linking)
VI  - 269
IP  - 7
DP  - 2012 Jul
TI  - Increased percentage of T cells with the expression of CD127 and CD132 in 
      hypertrophic adenoid in children with otitis media with effusion.
PG  - 1821-5
LID - 10.1007/s00405-012-1977-8 [doi]
AB  - The hypertrophic adenoid may promote chronic suppurative otitis media in children 
      as it fulfills its immune function. The number of lymphocytes in the adenoid and 
      their cooperation in the immune response depend of on their proliferation and 
      migration to the effector sites. Interleukin 7 (IL-7) is essential for the normal 
      development and function lymphocytes. IL-7 plays pivotal role for activation and 
      proliferation of T and B cells. The heterodimeric interleukin-7 receptor (IL-7R) 
      is composed of the IL-7Ralpha (127) and the common cytokine receptor gammac (CD132). The 
      aim of this study was to evaluate the percentage of lymphocytes T (CD4(+) and 
      CD8(+)) with IL-7R (CD127 and CD132) expression in hypertrophic adenoid in 
      children suffering with otitis media with effusion for a duration of 3 months. 
      Adenoid excised due to hypertrophy with or without chronic otitis media with 
      effusion was used as study material. CD4(+) CD127(+), CD4(+)132(+), 
      CD8(+)CD127(+) and CD8(+)CD132(+) cell subpopulations were identified using 
      monoclonal antibodies and flow cytometry. The percentage of CD4(+) and CD8(+) T 
      cells with CD127 receptor expression in hypertrophic adenoid of children with 
      otitis media with effusion was statistically significantly higher than in 
      hypertrophic adenoid group. The percentage of CD4(+) T cells with CD132 
      expression in the study group was statistically significantly higher than in the 
      reference group. The percentage of CD8(+) T cells with CD132(+) expression was 
      not statistically different in both groups. The increased percentage of T 
      lymphocytes with IL-7R expression (CD127 and CD132) in hypertrophic adenoid seems 
      to influence the quantity of lymphocytes and upset the immunological function of 
      tonsils which can influence the course of otitis media with effusion.
FAU - Zelazowska-Rutkowska, Beata
AU  - Zelazowska-Rutkowska B
AD  - Department of Pediatric Laboratory Diagnostics, Medical University of Bialystok, 
      Waszyngtona 17, 15-274 Bialystok, Poland. zelazowskab@wp.pl
FAU - Wysocka, Jolanta
AU  - Wysocka J
FAU - Ratomski, Karol
AU  - Ratomski K
FAU - Kasprzycka, Edwina
AU  - Kasprzycka E
FAU - Skotnicka, Bozena
AU  - Skotnicka B
LA  - eng
PT  - Journal Article
DEP - 20120302
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
RN  - 0 (Interleukin Receptor Common gamma Subunit)
RN  - 0 (Interleukin-7)
RN  - 0 (Interleukin-7 Receptor alpha Subunit)
SB  - IM
MH  - Adenoidectomy/methods
MH  - *Adenoids/immunology/pathology/surgery
MH  - Adolescent
MH  - B-Lymphocytes/*immunology
MH  - Cell Movement/immunology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Flow Cytometry/methods
MH  - Humans
MH  - *Hypertrophy/complications/immunology/surgery
MH  - Immunity, Cellular/immunology
MH  - Interleukin Receptor Common gamma Subunit/*metabolism
MH  - Interleukin-7/metabolism
MH  - Interleukin-7 Receptor alpha Subunit/*metabolism
MH  - Lymphocyte Count/methods
MH  - Male
MH  - *Otitis Media with Effusion/etiology/immunology
MH  - Palatine Tonsil/immunology
MH  - T-Lymphocytes/*immunology
PMC - PMC3365238
EDAT- 2012/03/03 06:00
MHDA- 2013/04/10 06:00
PMCR- 2012/03/02
CRDT- 2012/03/03 06:00
PHST- 2011/11/23 00:00 [received]
PHST- 2012/02/17 00:00 [accepted]
PHST- 2012/03/03 06:00 [entrez]
PHST- 2012/03/03 06:00 [pubmed]
PHST- 2013/04/10 06:00 [medline]
PHST- 2012/03/02 00:00 [pmc-release]
AID - 1977 [pii]
AID - 10.1007/s00405-012-1977-8 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2012 Jul;269(7):1821-5. doi: 
      10.1007/s00405-012-1977-8. Epub 2012 Mar 2.