PMID- 22382523
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20211021
IS  - 1993-0402 (Electronic)
IS  - 1672-0415 (Linking)
VI  - 18
IP  - 6
DP  - 2012 Jun
TI  - Protective effect of Chinese herbs for supplementing qi, nourishing yin and 
      activating blood circulation on heart function of patients with acute coronary 
      syndrome after percutaneous coronary intervention.
PG  - 423-30
LID - 10.1007/s11655-012-0966-5 [doi]
AB  - OBJECTIVE: To investigate the effects of Chinese herbs for supplementing qi, 
      nourishing yin and activating blood circulation on heart function of patients 
      with acute coronary syndrome (ACS) after successful percutaneous coronary 
      intervention (PCI). METHODS: One hundred patients with ACS after successful PCI 
      were randomly assigned to a Western medicine (WM) treatment group (WMG) and a 
      combined treatment group (CMG) treated by Chinese herbs for supplementing qi, 
      nourishing yin and activating blood circulation, besides Western medicine 
      treatment, with 50 cases in each group. Both treatment courses were 6 months. The 
      followup was scheduled at baseline, 6 months and 1 year after PCI, and New York 
      Heart Association (NYHA) functional class, Chinese medicine (CM) symptom scores, 
      blood stasis syndrome scores, and major adverse cardiovascular events (MACE) were 
      observed, serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) 
      and hyper-sensitivity C-reactive protein (Hs-CRP) were measured, an 
      echocardiogram was conducted to examine left ventricular ejection fraction 
      (LVEF), left ventricular end-diastolic volume (LVEDV), left ventricular 
      end-systolic volume (LVESV), inter-ventricular septal thickness (IVST), left 
      ventricular posterior wall thickness (LVPWT), and ventricular wall motion index 
      (VWMI). RESULTS: Compared with the baseline, LVEF significantly increased 
      (P<0.01), and CM symptom scores, blood stasis syndrome scores, VWMI, LVEDV, 
      LVESV, NT-proBNP, and Hs-CRP all decreased (P<0.01) in both groups at 6 months 
      and at 1 year after PCI. There were no significant differences in all the above 
      parameters at 1 year vs those at 6 months after PCI (P>0.05). VWMI, LVEDV, LVESV, 
      NT-proBNP, Hs-CRP, LVEF, and CM symptom and blood stasis syndrome scores were all 
      improved obviously in CMG than those in WMG (P<0.05 or P<0.01) at 6 months and at 
      1 year after PCI. There were no significant differences in NYHA functional class 
      between CMG and WMG at different follow-up timepoints; it was notable that value 
      was 0.054 when comparing the cases of NYHA functional class between the two 
      groups at 1-year follow-up. During the 1-year follow-up, 3 MACE and 11 MACE 
      occurred in CMG and WMG, respectively; the MACE rate in CMG was lower than that 
      in WMG (6% vs 22%, P<0.05). CONCLUSION: Chinese herbs for supplementing qi, 
      nourishing yin and activating blood circulation could improve heart function, 
      reduce the CM symptom scores and blood stasis syndrome scores, and decrease the 
      incidence of MACE in patients with ACS after successful PCI.
FAU - Liu, Hong-ying
AU  - Liu HY
AD  - Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing (100091), 
      China.
FAU - Wang, Wei
AU  - Wang W
FAU - Shi, Da-zhuo
AU  - Shi DZ
FAU - Ge, Jun-bo
AU  - Ge JB
FAU - Zhang, Lei
AU  - Zhang L
FAU - Peng, Juan
AU  - Peng J
FAU - Wang, Cheng-long
AU  - Wang CL
FAU - Wang, Pei-li
AU  - Wang PL
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20120229
PL  - China
TA  - Chin J Integr Med
JT  - Chinese journal of integrative medicine
JID - 101181180
RN  - 0 (Cardiotonic Agents)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Acute Coronary Syndrome/blood/*drug therapy/*physiopathology/surgery
MH  - C-Reactive Protein/metabolism
MH  - Cardiotonic Agents/adverse effects/pharmacology/therapeutic use
MH  - China/epidemiology
MH  - *Coronary Circulation/drug effects
MH  - Drugs, Chinese Herbal/adverse effects/pharmacology/*therapeutic use
MH  - Female
MH  - Heart Function Tests/drug effects
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - New York
MH  - Peptide Fragments/blood
MH  - *Percutaneous Coronary Intervention/adverse effects
MH  - Postoperative Complications/epidemiology/etiology
MH  - *Qi
MH  - Societies, Medical
MH  - Syndrome
MH  - Ultrasonography
MH  - *Yin-Yang
EDAT- 2012/03/03 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/03/03 06:00
PHST- 2010/02/01 00:00 [received]
PHST- 2012/03/03 06:00 [entrez]
PHST- 2012/03/03 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - 10.1007/s11655-012-0966-5 [doi]
PST - ppublish
SO  - Chin J Integr Med. 2012 Jun;18(6):423-30. doi: 10.1007/s11655-012-0966-5. Epub 
      2012 Feb 29.