PMID- 22383629
OWN - NLM
STAT- MEDLINE
DCOM- 20130610
LR  - 20120620
IS  - 1464-3553 (Electronic)
IS  - 0379-864X (Linking)
VI  - 37
IP  - 6
DP  - 2012 Jul
TI  - Goalpha expression in the vomeronasal organ and olfactory bulb of the tammar wallaby.
PG  - 567-77
LID - 10.1093/chemse/bjs040 [doi]
AB  - The vomeronasal organ (VNO) detects pheromones via 2 large families of receptors: 
      vomeronasal receptor 1, associated with the protein Gialpha2, and vomeronasal 
      receptor 2, associated with Goalpha. We investigated the distribution of Goalpha in the 
      developing and adult VNO and adult olfactory bulb of a marsupial, the tammar 
      wallaby. Some cells expressed Goalpha as early as day 5 postpartum, but by day 30, 
      Goalpha expressing cells were distributed throughout the receptor epithelium of the 
      VNO. In the adult tammar, Goalpha appeared to be expressed in sensory neurons whose 
      nuclei were mostly basally located in the vomeronasal receptor epithelium. Goalpha 
      expressing vomeronasal receptor cells led to all areas of the accessory olfactory 
      bulb (AOB). The lack of regionally restricted projection of the vomeronasal 
      receptor cell type 2 in the tammar was similar to the uniform type, with the 
      crucial difference that the uniform type only shows expression of Gialpha2 and no 
      expression of Goalpha. The observed Goalpha staining pattern suggests that the tammar may 
      have a third accessory olfactory type that could be intermediate to the 
      segregated and uniform types already described.
FAU - Schneider, Nanette Y
AU  - Schneider NY
AD  - The Australian Research Council Centre of Excellence in Kangaroo Genomics, 
      Department of Zoology, The University of Melbourne, Victoria 3010, Australia. 
      nanette@finistere-virtuell.de
FAU - Fletcher, Terrence P
AU  - Fletcher TP
FAU - Shaw, Geoff
AU  - Shaw G
FAU - Renfree, Marilyn B
AU  - Renfree MB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120301
PL  - England
TA  - Chem Senses
JT  - Chemical senses
JID - 8217190
RN  - EC 3.6.5.1 (GTP-Binding Protein alpha Subunits, Gi-Go)
SB  - IM
MH  - Animals
MH  - Female
MH  - GTP-Binding Protein alpha Subunits, Gi-Go/analysis/*biosynthesis
MH  - Macropodidae/*metabolism
MH  - Male
MH  - Mice
MH  - Olfactory Bulb/*metabolism
MH  - Vomeronasal Organ/*metabolism
EDAT- 2012/03/03 06:00
MHDA- 2013/06/12 06:00
CRDT- 2012/03/03 06:00
PHST- 2012/03/03 06:00 [entrez]
PHST- 2012/03/03 06:00 [pubmed]
PHST- 2013/06/12 06:00 [medline]
AID - bjs040 [pii]
AID - 10.1093/chemse/bjs040 [doi]
PST - ppublish
SO  - Chem Senses. 2012 Jul;37(6):567-77. doi: 10.1093/chemse/bjs040. Epub 2012 Mar 1.