PMID- 22383923
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1918-3011 (Electronic)
IS  - 1918-3003 (Print)
IS  - 1918-3003 (Linking)
VI  - 4
IP  - 1
DP  - 2012 Feb
TI  - The importance of cardiac biomarkers on remodelling after myocardial infarction.
PG  - 20-5
LID - 10.4021/jocmr759w [doi]
AB  - BACKGROUND: The purpose of this study is to evaluate the importance of tenascin-C 
      ( TNC), N-terminal pro brain natriuretic peptide (NT-proBNP) and C-reactive 
      protein (CRP) on LV remodelling after myocardial infarction (MI). METHODS: 
      Fifty-seven stable patients with subacute anterior MI who had total or subtotal 
      occlusion in the infarct-related left anterior desending artery in coronary 
      angiography were enrolled the study. 18 of patients who had total occlusion 
      received only medical theraphy, 19 of patients who had total occlusion received 
      successful PCI+ medical theraphy and 20 of patients who had subtotal occlusion 
      received successful PCI+ medical theraphy. Left ventricular volumes and ejection 
      fractions (EF) were measured with echocardiography. Serum TNC, NT-proBNP and CRP 
      levels were measured at admission and a month after treatment. RESULTS: There was 
      significant increase in LV end-diastolic volume (LVEDV) and LV end-systolic 
      volume (LVESV) baseline to follow-up in total-PCI group. Baseline to follow-up; a 
      borderline significant increase was observed in LVEDV in the total-medical group. 
      No significant difference was seen in LV volumes and EF in the subtotal-PCI 
      group. NT-proBNP, TNC and CRP levels were decreased in all groups. The decrease 
      in NT-proBNP and CRP values were significant in the total-medical and 
      subtotal-PCI group but in the total-PCI group they were not significant. The 
      decrease of TNC was significant in all groups but the lowest decrease was seen in 
      the total-PCI group. CONCLUSION: TNC, NT-proBNP and CRP reflect LV remodelling in 
      accordance with echocardiography after MI. KEYWORDS: Tenascin-C; NT-pro BNP; CRP; 
      Remodelling; Myocardial infarction.
FAU - Celik, Ahmet
AU  - Celik A
AD  - Department of Cardiology, Elazig Education and Research Hospital, Elazig, Turkey.
FAU - Kalay, Nihat
AU  - Kalay N
FAU - Sahin, Omer
AU  - Sahin O
FAU - Duran, Mustafa
AU  - Duran M
FAU - Korkmaz, Hasan
AU  - Korkmaz H
FAU - Kobat, Mehmet Ali
AU  - Kobat MA
FAU - Kurtoglu, Ertugrul
AU  - Kurtoglu E
FAU - Dogan, Ali
AU  - Dogan A
FAU - Muhtaroglu, Sabahattin
AU  - Muhtaroglu S
FAU - Baran, Oguzhan
AU  - Baran O
FAU - Inanc, Mehmet Tugrul
AU  - Inanc MT
FAU - Ozdogru, Ibrahim
AU  - Ozdogru I
FAU - Oguzhan, Abdurrahman
AU  - Oguzhan A
FAU - Topsakal, Ramazan
AU  - Topsakal R
LA  - eng
PT  - Journal Article
DEP - 20120117
PL  - Canada
TA  - J Clin Med Res
JT  - Journal of clinical medicine research
JID - 101538301
PMC - PMC3279497
EDAT- 2012/03/03 06:00
MHDA- 2012/03/03 06:01
PMCR- 2012/02/01
CRDT- 2012/03/03 06:00
PHST- 2011/11/11 00:00 [accepted]
PHST- 2012/03/03 06:00 [entrez]
PHST- 2012/03/03 06:00 [pubmed]
PHST- 2012/03/03 06:01 [medline]
PHST- 2012/02/01 00:00 [pmc-release]
AID - 10.4021/jocmr759w [doi]
PST - ppublish
SO  - J Clin Med Res. 2012 Feb;4(1):20-5. doi: 10.4021/jocmr759w. Epub 2012 Jan 17.