PMID- 22384844
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20191112
IS  - 1873-4251 (Electronic)
IS  - 1570-162X (Linking)
VI  - 10
IP  - 3
DP  - 2012 Apr
TI  - The anemia prevalence and the association between complete blood count analysis 
      and renal function parameters in HIV-1-infected patients.
PG  - 247-51
AB  - OBJECTIVES: To determine the anemia prevalence and the correlation between 
      complete blood count (CBC) analysis and renal function parameters in 
      HIV-1-infected population. METHODS: It was a single-center study set in Warsaw 
      (Poland) over a 3-year period. The study was performed in 214 adult HIV-1- 
      infected patients (180 males and 34 females, aged from 20 to 69 years old, mean 
      age 39.55 years, 130 on combined antiretroviral therapy, cART). Glomerular 
      filtration rate (GFR) was estimated using the re-expressed Modification of Diet 
      in Renal Disease (MDRD) and the Chronic Kidney Disease Epidemiology Collaboration 
      (CKD-EPI) formulas. In statistical analyses U Mann-Whitney and Spearman 
      correlation test as logistic regression analysis was used. RESULTS: 25.2% of 
      studied patients were anemic. In all of them, estimated GFR (eGFR) was positively 
      correlated with red blood cells (RBC) and platelet (PLT) count, and negatively 
      correlated with mean corpuscular volume (MCV) and mean corpuscular hemoglobin 
      concentration (MCHC). All these correlations were statistically significant (p < 
      0.001) and independent of gender and used type of eGFR formula. In logistic 
      regression analysis, lower eGFR strongly predicted lower RBC and PLT levels (p < 
      0.0001; OR 0.08, 95%CI: 0.03, 0.22 and OR 0.99, 95%CI: 0.987, 0.993, 
      respectively). CONCLUSIONS: Our findings suggest a strong association between CBC 
      and renal function in ARV-treated HIV-infected patients who fulfilled the 
      criteria of anemia. Consequently, eGFR in all HIV-infected subjects with anemia, 
      especially on treatment with nephrotoxic drugs and concomitant thrombocytopenia, 
      should be monitored more frequently then standardly recommended every 3-6 months.
FAU - Dabrowska, Magdalena M
AU  - Dabrowska MM
AD  - Department of Hepatology and Acquired Immunodeficiences, Warsaw Medical 
      University, 37 Wolska Street, 01-201 Warsaw, Poland. m.dabrowska@op.pl
FAU - Mikula, Tomasz
AU  - Mikula T
FAU - Wiercinska-Drapalo, Alicja
AU  - Wiercinska-Drapalo A
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Curr HIV Res
JT  - Current HIV research
JID - 101156990
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/blood/complications/*epidemiology
MH  - Adult
MH  - Aged
MH  - Anemia/blood/*epidemiology/virology
MH  - *Blood Cell Count
MH  - Cohort Studies
MH  - Creatinine/*blood
MH  - Female
MH  - Glomerular Filtration Rate
MH  - *HIV-1/metabolism
MH  - Humans
MH  - Kidney Failure, Chronic/blood/complications/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - Platelet Count
MH  - Poland/epidemiology
MH  - Prevalence
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2012/03/06 06:00
MHDA- 2012/09/11 06:00
CRDT- 2012/03/06 06:00
PHST- 2011/04/06 00:00 [received]
PHST- 2012/01/24 00:00 [revised]
PHST- 2012/02/21 00:00 [accepted]
PHST- 2012/03/06 06:00 [entrez]
PHST- 2012/03/06 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
AID - CHIVR-EPUB-20120229-006 [pii]
AID - 10.2174/157016212800618147 [doi]
PST - ppublish
SO  - Curr HIV Res. 2012 Apr;10(3):247-51. doi: 10.2174/157016212800618147.