PMID- 22385549
OWN - NLM
STAT- MEDLINE
DCOM- 20120713
LR  - 20171116
IS  - 1933-2874 (Print)
IS  - 1876-4789 (Linking)
VI  - 6
IP  - 2
DP  - 2012 Mar-Apr
TI  - Relationship between serum uric acid and metabolic syndrome: an analysis by 
      structural equation modeling.
PG  - 159-67
LID - 10.1016/j.jacl.2011.11.006 [doi]
AB  - OBJECTIVE: To investigate the nature of the relationships between uric acid and 
      metabolic syndrome (MetS) components. METHODS: Body mass index, waist 
      circumference, serum uric acid, fasting glucose, lipid profiles, and blood 
      pressure were measured in 13,811 subjects aged between 18 and 85 years of age. 
      Two structural equation models (SEMs) were used to test a hypothesis regarding 
      the linking roles of uric acid in the occurrence of MetS components in male and 
      female separately. RESULTS: The findings of the SEM demonstrated that increased 
      uric acid level was associated with fasting glucose (beta = 0.221, P < .001), 
      blood pressure (beta = 0.158, P < .001), and lipid profiles (beta = 0.391, P < 
      .001) in women. Increased uric acid level was associated with decreased fasting 
      glucose (beta = -0.071, P < .001) and increased lipid profiles (beta = 0.352, P < 
      .001) in men. The association was stronger between uric acid and lipid profiles 
      than those between uric acid and other MetS components. CONCLUSION: By using SEM, 
      we were able to confirm the intimate relationships between uric acid and MetS 
      components, particularly in women. The associations between uric acid and MetS 
      components were gender specific, and the nature of such association requires 
      further exploration.
CI  - Copyright A(c) 2012 National Lipid Association. Published by Elsevier Inc. All 
      rights reserved.
FAU - Lu, Wenli
AU  - Lu W
AD  - Department of Health Statistics, School of Public Health, Tianjin Medical 
      University, Tianjin, China.
FAU - Song, Kun
AU  - Song K
FAU - Wang, Yuan
AU  - Wang Y
FAU - Zhang, Qing
AU  - Zhang Q
FAU - Li, Wen
AU  - Li W
FAU - Jiao, Huanli
AU  - Jiao H
FAU - Wang, Guolin
AU  - Wang G
FAU - Huang, Guowei
AU  - Huang G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20111204
PL  - United States
TA  - J Clin Lipidol
JT  - Journal of clinical lipidology
JID - 101300157
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Male
MH  - Metabolic Syndrome/*blood/complications/diagnosis/*epidemiology
MH  - Middle Aged
MH  - *Models, Statistical
MH  - Uric Acid/*blood
MH  - Young Adult
EDAT- 2012/03/06 06:00
MHDA- 2012/07/14 06:00
CRDT- 2012/03/06 06:00
PHST- 2011/06/02 00:00 [received]
PHST- 2011/11/08 00:00 [revised]
PHST- 2011/11/21 00:00 [accepted]
PHST- 2012/03/06 06:00 [entrez]
PHST- 2012/03/06 06:00 [pubmed]
PHST- 2012/07/14 06:00 [medline]
AID - S1933-2874(11)00828-2 [pii]
AID - 10.1016/j.jacl.2011.11.006 [doi]
PST - ppublish
SO  - J Clin Lipidol. 2012 Mar-Apr;6(2):159-67. doi: 10.1016/j.jacl.2011.11.006. Epub 
      2011 Dec 4.