PMID- 22385945
OWN - NLM
STAT- MEDLINE
DCOM- 20120924
LR  - 20211021
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Print)
IS  - 1071-9164 (Linking)
VI  - 18
IP  - 3
DP  - 2012 Mar
TI  - A positive 2-item Patient Health Questionnaire depression screen among 
      hospitalized heart failure patients is associated with elevated 12-month 
      mortality.
PG  - 238-45
LID - 10.1016/j.cardfail.2011.11.002 [doi]
AB  - BACKGROUND: Given the association of depression with poorer cardiac outcomes, an 
      American Heart Association Science Advisory has advocated routine screening of 
      cardiac patients for depression using the 2-item Patient Health Questionnaire 
      (PHQ-2) "at a minimum." However, the prognostic value of the PHQ-2 among HF 
      patients is unknown. METHODS AND RESULTS: We screened hospitalized HF patients 
      (ejection fraction [EF] <40%) that staff suspected may be depressed with the 
      PHQ-2, and then determined vital status at up to 12-months follow-up. At 
      baseline, PHQ-2 depression screen-positive patients (PHQ-2+; n = 371), compared 
      with PHQ-2 screen-negative patients (PHQ-2-; n = 100), were younger (65 vs 70 
      years) and more likely to report New York Heart Association (NYHA) functional 
      class III/IV than class II symptoms (67% vs. 39%) and lower levels of physical 
      and mental health-related quality of life (all P </= .002); they were similar in 
      other characteristics (65% male, 26% mean EF). At 12 months, 20% of PHQ-2+ versus 
      8% of PHQ-2- patients had died (P = .007) and PHQ-2 status remained associated 
      with both all-cause (hazard ratio [HR] 3.1, 95% confidence interval [CI] 1.4-6.7; 
      P = .003) and cardiovascular (HR 2.7, 95% CI 1.1-6.6; P = .03) mortality even 
      after adjustment for age, gender, EF, NYHA functional class, and a variety of 
      other covariates. CONCLUSIONS: Among hospitalized HF patients, a positive PHQ-2 
      depression screen is associated with an elevated 12-month mortality risk.
CI  - Copyright A(c) 2012 Elsevier Inc. All rights reserved.
FAU - Rollman, Bruce L
AU  - Rollman BL
AD  - Division of General Internal Medicine, Center for Research on Health Care, 
      University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. 
      rollmanbl@upmc.edu
FAU - Herbeck Belnap, Bea
AU  - Herbeck Belnap B
FAU - Mazumdar, Sati
AU  - Mazumdar S
FAU - Houck, Patricia R
AU  - Houck PR
FAU - He, Fanyin
AU  - He F
FAU - Alvarez, Rene J
AU  - Alvarez RJ
FAU - Schulberg, Herbert C
AU  - Schulberg HC
FAU - Reynolds, Charles F 3rd
AU  - Reynolds CF 3rd
FAU - McNamara, Dennis M
AU  - McNamara DM
LA  - eng
GR  - R34 MH078030/MH/NIMH NIH HHS/United States
GR  - R34 MH078030-03/MH/NIMH NIH HHS/United States
GR  - UL1 RR024153/RR/NCRR NIH HHS/United States
GR  - UL1 TR000005/TR/NCATS NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
DEP - 20111222
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Depression/*diagnosis/*mortality/psychology
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*mortality/*psychology
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Mass Screening/*methods
MH  - Middle Aged
MH  - *Surveys and Questionnaires
MH  - Survival Rate
MH  - Time Factors
MH  - Young Adult
PMC - PMC3298032
MID - NIHMS340528
EDAT- 2012/03/06 06:00
MHDA- 2012/09/25 06:00
PMCR- 2013/03/01
CRDT- 2012/03/06 06:00
PHST- 2011/03/16 00:00 [received]
PHST- 2011/11/15 00:00 [revised]
PHST- 2011/11/17 00:00 [accepted]
PHST- 2012/03/06 06:00 [entrez]
PHST- 2012/03/06 06:00 [pubmed]
PHST- 2012/09/25 06:00 [medline]
PHST- 2013/03/01 00:00 [pmc-release]
AID - S1071-9164(11)01288-7 [pii]
AID - 10.1016/j.cardfail.2011.11.002 [doi]
PST - ppublish
SO  - J Card Fail. 2012 Mar;18(3):238-45. doi: 10.1016/j.cardfail.2011.11.002. Epub 
      2011 Dec 22.