PMID- 22386367
OWN - NLM
STAT- MEDLINE
DCOM- 20120919
LR  - 20171116
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 66
IP  - 2
DP  - 2012 Mar
TI  - Regulation of CD44 expression by tumor necrosis factor-alpha and its potential role 
      in breast cancer cell migration.
PG  - 144-50
LID - 10.1016/j.biopha.2011.11.021 [doi]
AB  - CD44 molecule plays critical role in distant malignant metastasis. It is 
      expressed in standard form (CD44s) or variant form (CD44v). Tumor necrosis 
      factor-alpha (TNF-alpha) is highly expressed in the cancer microenvironment. TNF-alpha was 
      reported to modulate CD44 expression in several kinds of cancer. However, little 
      is known about pathological role of TNF-alpha in breast cancer (BC) cells. In the 
      current investigation, we investigated the effect of TNF-alpha on BC cells (MCF-7 and 
      MDA-MB-231) viability, CD44 expression, and in vitro migration. We found that 
      TNF-alpha down-regulated CD44s expression, up-regulated CD44v3 and CD44v6 expression 
      through JNK pathway in MCF-7 cells. In MDA-MB-231 cells, TNF-alpha up-regulated 
      CD44s, CD44v3 and CD44v6 expression via p38 pathway. These data indicate 
      important role of CD44 molecule in BC pathology.
CI  - Copyright (c) 2012 Elsevier Masson SAS. All rights reserved.
FAU - Li, Jun
AU  - Li J
AD  - Department of Medical Oncology, The First Affiliated Hospital of Nanjing Medical 
      University, 300 Guangzhou Road, 210029 Nanjing, PR China.
FAU - Zha, Xiao-Ming
AU  - Zha XM
FAU - Wang, Rong
AU  - Wang R
FAU - Li, Xiao-Dong
AU  - Li XD
FAU - Xu, Bei
AU  - Xu B
FAU - Xu, Yan-Jie
AU  - Xu YJ
FAU - Yin, Yong-Mei
AU  - Yin YM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120217
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (CD44S antigen)
RN  - 0 (CD44V3,8-10)
RN  - 0 (CD44v6 antigen)
RN  - 0 (Hyaluronan Receptors)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Breast Neoplasms/*pathology
MH  - Cell Line, Tumor
MH  - Cell Movement/*physiology
MH  - Cell Survival/physiology
MH  - Down-Regulation/physiology
MH  - Female
MH  - Gene Expression Regulation, Neoplastic/*physiology
MH  - Humans
MH  - Hyaluronan Receptors/*genetics
MH  - MAP Kinase Signaling System/physiology
MH  - Tumor Necrosis Factor-alpha/*physiology
MH  - Up-Regulation/physiology
EDAT- 2012/03/06 06:00
MHDA- 2012/09/20 06:00
CRDT- 2012/03/06 06:00
PHST- 2011/10/06 00:00 [received]
PHST- 2011/11/08 00:00 [accepted]
PHST- 2012/03/06 06:00 [entrez]
PHST- 2012/03/06 06:00 [pubmed]
PHST- 2012/09/20 06:00 [medline]
AID - S0753-3322(12)00009-1 [pii]
AID - 10.1016/j.biopha.2011.11.021 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2012 Mar;66(2):144-50. doi: 10.1016/j.biopha.2011.11.021. 
      Epub 2012 Feb 17.