PMID- 22386373
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20220321
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 84
IP  - 2
DP  - 2012 Oct 1
TI  - Effective dose reduction to cardiac structures using protons compared with 3DCRT 
      and IMRT in mediastinal Hodgkin lymphoma.
PG  - 449-55
LID - 10.1016/j.ijrobp.2011.12.034 [doi]
AB  - PURPOSE: We investigated the dosimetric impact of proton therapy (PT) on various 
      cardiac subunits in patients with Hodgkin lymphoma (HL). METHODS AND MATERIALS: 
      From June 2009 through December 2010, 13 patients were enrolled on an 
      institutional review board-approved protocol for consolidative involved-node 
      radiotherapy (INRT) for HL. Three separate treatment plans were developed 
      prospectively by using three-dimensional conformal radiotherapy (3DCRT), 
      intensity-modulated radiotherapy (IMRT), and PT. Cardiac subunits were 
      retrospectively contoured on the 11 patients with intravenous-contrast simulation 
      scans, and the doses were calculated for all treatment plans. A Wilcoxon paired 
      test was performed to evaluate the statistical significance (p < 0.05) of 3DCRT 
      and IMRT compared with PT. RESULTS: The mean heart doses were 21 Gy, 12 Gy, and 8 
      Gy (relative biologic effectiveness [RBE]) with 3DCRT, IMRT, and PT, 
      respectively. Compared with 3DCRT and IMRT, PT reduced the mean doses to the left 
      and right atria; the left and right ventricles; the aortic, mitral, and tricuspid 
      valves; and the left anterior descending, left circumflex, and right circumflex 
      coronary arteries. CONCLUSIONS: Compared with 3DCRT and IMRT, PT reduced the 
      radiation doses to all major cardiac subunits. Limiting the doses to these 
      structures should translate into lower rates of cardiac toxicities.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Hoppe, Bradford S
AU  - Hoppe BS
AD  - Department of Radiation Oncology, University of Florida Proton Therapy Institute, 
      Jacksonville, FL 32206, USA. bhoppe@floridaproton.org
FAU - Flampouri, Stella
AU  - Flampouri S
FAU - Su, Zhong
AU  - Su Z
FAU - Latif, Naeem
AU  - Latif N
FAU - Dang, Nam H
AU  - Dang NH
FAU - Lynch, James
AU  - Lynch J
FAU - Joyce, Michael
AU  - Joyce M
FAU - Sandler, Eric
AU  - Sandler E
FAU - Li, Zuofeng
AU  - Li Z
FAU - Mendenhall, Nancy P
AU  - Mendenhall NP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120302
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
RN  - 0 (Protons)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Female
MH  - Heart/diagnostic imaging/*radiation effects
MH  - Hodgkin Disease/diagnostic imaging/*radiotherapy
MH  - Humans
MH  - Male
MH  - Mediastinal Neoplasms/diagnostic imaging/*radiotherapy
MH  - Organs at Risk/diagnostic imaging/*radiation effects
MH  - *Proton Therapy
MH  - Radiation Injuries/prevention & control
MH  - Radiography
MH  - Radionuclide Imaging
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/methods
MH  - Radiotherapy, Conformal/*methods
MH  - Radiotherapy, Intensity-Modulated/methods
MH  - Young Adult
EDAT- 2012/03/06 06:00
MHDA- 2012/11/14 06:00
CRDT- 2012/03/06 06:00
PHST- 2011/10/23 00:00 [received]
PHST- 2011/10/25 00:00 [revised]
PHST- 2011/12/08 00:00 [accepted]
PHST- 2012/03/06 06:00 [entrez]
PHST- 2012/03/06 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
AID - S0360-3016(11)03721-7 [pii]
AID - 10.1016/j.ijrobp.2011.12.034 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2012 Oct 1;84(2):449-55. doi: 
      10.1016/j.ijrobp.2011.12.034. Epub 2012 Mar 2.