PMID- 22386694
OWN - NLM
STAT- MEDLINE
DCOM- 20130118
LR  - 20120427
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 73
IP  - 5
DP  - 2012 May
TI  - Plasmacytoid dendritic cells and their Toll-like receptor 9 expression 
      selectively decrease with age.
PG  - 493-7
LID - 10.1016/j.humimm.2012.02.007 [doi]
AB  - Dendritic cells (DCs) play a crucial role in the initiation of immune responses 
      against infectious particles and tumor cells; however, the impact of age, 
      anthropometric parameters, and gender on the number and the expression of 
      function-associated molecules of human DCs is poorly understood. In this study, 
      blood DCs of 50 volunteers (19-84 years old) with no acute or chronic 
      inflammatory diseases were examined using 4-color flow cytometry. Increasing age 
      was associated with a decrease in blood plasmacytoid, but not myeloid DCs and a 
      selective decrease in Toll-like receptor 9 (TLR9) expression by plasmacytoid DCs. 
      In contrast, gender and body mass index did not impact the number of DC subsets 
      or the expression of function-associated DC molecules. Thus, we demonstrate that 
      age has a selective impact on plasmacytoid DCs and their TLR9 expression. This 
      may contribute to an increased susceptibility to infections and tumors with 
      increasing age.
CI  - Copyright (c) 2012 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Garbe, Katharina
AU  - Garbe K
AD  - Department of Pneumology, University of Rostock, 18057 Rostock, Germany.
FAU - Bratke, Kai
AU  - Bratke K
FAU - Wagner, Stefanie
AU  - Wagner S
FAU - Virchow, Johann Christian
AU  - Virchow JC
FAU - Lommatzsch, Marek
AU  - Lommatzsch M
LA  - eng
PT  - Journal Article
DEP - 20120216
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Antigens, CD)
RN  - 0 (TLR9 protein, human)
RN  - 0 (Toll-Like Receptor 9)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - *Aging
MH  - Antigens, CD/biosynthesis/immunology
MH  - Body Mass Index
MH  - Dendritic Cells/cytology/immunology/*metabolism
MH  - Female
MH  - Flow Cytometry
MH  - Gene Expression/*immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myeloid Cells/cytology/immunology/*metabolism
MH  - Toll-Like Receptor 9/*biosynthesis/immunology
EDAT- 2012/03/06 06:00
MHDA- 2013/01/19 06:00
CRDT- 2012/03/06 06:00
PHST- 2011/09/23 00:00 [received]
PHST- 2012/01/30 00:00 [revised]
PHST- 2012/02/10 00:00 [accepted]
PHST- 2012/03/06 06:00 [entrez]
PHST- 2012/03/06 06:00 [pubmed]
PHST- 2013/01/19 06:00 [medline]
AID - S0198-8859(12)00042-0 [pii]
AID - 10.1016/j.humimm.2012.02.007 [doi]
PST - ppublish
SO  - Hum Immunol. 2012 May;73(5):493-7. doi: 10.1016/j.humimm.2012.02.007. Epub 2012 
      Feb 16.